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首页> 外文期刊>RSC Advances >Studies on the interaction of 2-amino-3-hydroxy-anthraquinone with surfactant micelles reveal its nucleation in human MDA-MB-231 breast adinocarcinoma cells
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Studies on the interaction of 2-amino-3-hydroxy-anthraquinone with surfactant micelles reveal its nucleation in human MDA-MB-231 breast adinocarcinoma cells

机译：2-氨基-3-羟基 - 蒽醌与表面活性剂胶束的相互作用的研究显示其在人MDA-MB-231乳腺癌细胞中的成核

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Structural and spectroscopic studies on 2-amino-3-hydroxy-anthraquinone (AQ), an analogue of anthracycline drugs, were carried out using computational methods. The interactions of AQ with anionic surfactant sodium dodecyl sulphate (SDS) and cationic surfactant cetyltrimethylammonium bromide (CTAB) were investigated in aqueous solution at physiological pH (7.4) by UV-Vis spectroscopy, and compared with the well-known anthracycline drugs. The affinity of such molecule to surfactant micelles may mean it can act as a model system for a biological membrane–drug interaction, which is important in determining the biological action of this molecule. The binding constant, partition coefficient and Gibbs free energy for the binding and distribution of AQ between the bulk aqueous solution and surfactant micelles were determined for AQ–surfactant interactions. It was observed that hydrophobic interaction plays a crucial role in the binding of AQ to SDS micelles, while the hydrophilic interaction plays an important role in its interaction with CTAB micelles. These interactions also have a vital role in the distribution of AQ between surfactant micelle–water phases. This study gives an idea that the present molecule may successfully permeate biological membranes, so AQ was allowed to interact with human breast adinocarcinoma cell MDA-MB-231. Experimental findings established that AQ induces apoptosis by means of nucleation into these cells.
机译：使用计算方法进行对2-氨基-3-羟基 - 蒽醌（AQ）的结构和光谱研究，进行蒽环类药物的类似物。通过UV-Vis光谱，在生理pH（7.4）的水溶液中研究了水溶液与阴离子表面活性剂十二烷基硫酸钠（SDS）和阳离子表面活性剂甲酰基三甲基溴化铵（CTAB）的相互作用，并与众所周知的蒽环类药物进行比较。这种分子对表面活性剂胶束的亲和力可能意味着它可以作为生物膜 - 药物相互作用的模型系统，这对于确定该分子的生物学作用是重要的。确定用于水溶液与表面活性剂胶束之间的Aq的结合和分布的结合常数，分区系数和Gibbs自由能，用于水溶液 - 表面活性剂相互作用。观察到疏水相互作用在AQ与SDS胶束的结合中起着至关重要的作用，而亲水性相互作用在其与CTAB胶束的相互作用中起重要作用。这些相互作用在表面活性剂胶束水相之间的AQ分布中也具有至关重要的作用。该研究表明，本分子可以成功渗透生物膜，使得水溶液与人乳腺癌细胞MDA-MB-231相互作用。实验结果确定了水溶病通过成核诱导细胞凋亡。

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