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首页> 外文期刊>RSC Advances >Polymeric micelles from block copolymers containing 2,6-diacylaminopyridine units for encapsulation of hydrophobic drugs
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Polymeric micelles from block copolymers containing 2,6-diacylaminopyridine units for encapsulation of hydrophobic drugs

机译：来自嵌段共聚物的聚合物胶束含有2,6-二酰胺吡啶单元，用于包封疏水性药物

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The paper describes the synthesis and characterization of novel amphiphilic block copolymers composed of a hydrophilic (polyethylene glycol) block and a hydrophobic polymetacrylate block with pendant 2,6-acylaminopyridine units. As demonstrated by TEM, these polymers are capable of forming stable spherical micelles in water with diameters of 18–25 nm, depending on the average molar mass, determined by dynamic light scattering. The polymeric micelles are sensitive to pH and can encapsulate hydrophobic molecules such as Nile Red. The cytotoxicity of the block copolymers has been tested in HeLa and Lunet cell lines and proved to be adequate. The polymeric micelles have been used to load camptothecin (CPT), an effective antiviral against hepatitis C virus (HCV), by simple physical diffusion. The antiviral activity against HVC of these CPT-loaded polymeric micelles has been tested on Huh 5-2 Lunet cells, demonstrating the potential of these polymers as nanocarriers for drug delivery applications.
机译：本文描述了由具有垂侧2,6-酰氨基吡啶单元的亲水性（聚乙二醇）嵌段和疏水聚丙烯酸酯嵌段组成的新型两亲嵌段共聚物的合成和表征。如TEM所证明的，这些聚合物能够在直径为18-25nm的水中在水中形成稳定的球形胶束，这取决于通过动态光散射确定的平均摩尔质量。聚合物胶束对pH敏感，并且可以包封疏水分子，例如尼罗红色。嵌段共聚物的细胞毒性已在Hela和呼吸细胞系中进行测试，并证明是足够的。通过简单的物理扩散，聚合物胶束已用于载有抗癌蛋白酶（CPT），对丙型肝炎病毒（HCV）有效抗病毒。针对这些CPT加载的聚合物胶束HVC的抗病毒活性已经在Huh 5-2呼吸呼吸射胶质细胞上测试，证明这些聚合物作为用于药物递送应用的纳米载体的潜力。

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