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首页> 外文期刊>Macromolecular symposia >Polymer-Drug Encapsulation using Various PEG- and Polypeptide-Based Block Copolymer Micelles
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Polymer-Drug Encapsulation using Various PEG- and Polypeptide-Based Block Copolymer Micelles

机译：使用各种基于PEG和多肽的嵌段共聚物胶束的聚合物-药物封装

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摘要

Various novel di-or tri-block copolymers with hydrophilic PEG and/or polylysine in association with hydrophobic polycaprolactone segments namely PEGb-PolyLys and PEG-b-PolyLys-b-PCL, have been synthesized and characterized. Poly(Lys-g-Glu)-b-PCL has been successfully synthesized where D-gluconolactone was grafted on the -NH_2 group of PolyLys. These copolymers self-assemble in water to form micelles in the size range 165 to 365 nm and CMC from 0.1 mg/ml to 2 mg/ml. Both micelle size and CMC showed a strong dependency on the hydrophobic chain length. The encapsulation of Ketoprofen and Rifampicin in the different copolymer families was assessed and encapsulation efficiency determined using UV Spectroscopy. The % drug loaded was found to depend on the interaction between drug and copolymer system. Both drugs showed chemical conjugation with PolyLys segment and physical entrapment in the PCL hydrophobic core. Higher encapsulation efficiency was obtained with Rifampicin (17-70%).
机译：已经合成和表征了具有亲水性PEG和/或聚赖氨酸以及疏水性聚己内酯链段的各种新型二嵌段或三嵌段共聚物，即PEGb-PolyLys和PEG-b-PolyLys-b-PCL。已经成功地合成了聚（Lys-g-Glu）-b-PCL，其中将D-葡糖酸内酯接​​枝到PolyLys的-NH_2基团上。这些共聚物在水中自组装形成尺寸为165至365 nm的胶束，CMC为0.1 mg / ml至2 mg / ml。胶束大小和CMC都显示出对疏水链长度的强烈依赖性。评估了酮洛芬和利福平在不同共聚物家族中的包封率，并使用紫外光谱法确定了包封率。发现载药％取决于药物与共聚物体系之间的相互作用。两种药物均显示化学结合，带有PolyLys片段，并在PCL疏水核心中物理捕获。使用利福平（17-70％）可获得更高的包封效率。

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