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Near-infrared light-induced imaging and targeted anti-cancer therapy based on a yolk/shell structure

机译：基于蛋黄/壳结构的近红外光诱导成像和靶向抗癌疗法

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To combine photodynamic therapy (PDT) and bio-imaging for improved antitumor efficacy, we design a yolk-like NaYF _(4) :Yb,Er@MgSiO _(3) –ZnPc–RGD mesoporous platform by encapsulating a photosensitive agent (ZnPc) and a targeted peptide, NH _(2) -Gly-Arg-Gly-Asp-Ser (RGD), into MgSiO _(3) mesoporous shell coated NaYF _(4) :Yb,Er spheres. A novel spinous MgSiO _(3) shell is synthesized by an in situ growth process without using any surfactant, instead of the conventional mesoporous silica shell. Upon 980 nm laser irradiation, the emitted red light matches well with the absorbance of ZnPc, which generates reactive oxygen species (ROS) to kill cancer cells, and the retained green light allows for real-time monitoring of the therapeutic process. The in vitro and in vivo results indicate that the platform shows excellent anti-cancer therapeutic efficacy under NIR laser irradiation due to the specialised intracellular transition pattern, avoiding premature leakout of ZnPc, and targeted accumulation in the cancer cell sites. Thus, we envision that our proposed platform should have great potential for PDT-induced tumor therapy and for monitoring biochemical changes taking place in live tumor cells.
机译：结合光动力治疗（PDT）和生物成像，以改善抗肿瘤功效，我们设计一种蛋黄样NayF _（4）：YB，ER @ MgSIO _（3）-ZNPC-RGD中孔平台通过包封光敏剂（ZnPC ）和靶向肽，NH _（2）-gly-Arg-Gly-Asp-Ser（RGD），进入MgSiO _（3）介孔壳涂覆的NayF _（4）：Yb，ER球体。一种新的棘突MgsiO _（3）壳由原位生长过程合成而不使用任何表面活性剂，而不是传统的介孔二氧化硅壳。在980nm激光照射时，发射的红光与ZnPC的吸光度相匹配，其产生反应性氧物种（ROS）杀死癌细胞，并且保留的绿光允许实时监测治疗过程。体外和体内结果表明，由于专用的细胞内转变模式，避免了ZnPC的过早泄漏和癌细胞位点的靶向积累，该平台显示出在NIR激光辐射下的优异的抗癌治疗效果。因此，我们设想我们所提出的平台应具有巨大的PDT诱导的肿瘤治疗和监测活肿瘤细胞中生化变化的潜力。

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