...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical and Diagnostic Research >Assessment of Corneal Endothelium among Diabetic Patients in a Multispecialty Hospital in Tamil Nadu
【24h】

Assessment of Corneal Endothelium among Diabetic Patients in a Multispecialty Hospital in Tamil Nadu

机译：泰米尔纳德邦多层医院糖尿病患者角膜内皮评估

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Corneal damage is the common issue affecting 70% of diabetic patients. Diabetic cornea has functional abnormalities such as decreased corneal Endothelial Cell Density (ECD), thicker corneas with increased endothelial permeability, lesser corneal sensitivity, and elevated corneal auto-fluorescence.Aim: To study the corneal endothelial characteristics among diabetic patients and to identify the factors associated with endothelial damage and compare the corneal changes based on the duration of diabetes mellitus and glycaemic control.Materials and Methods: The hospital based cross-sectional study was conducted in 155 patients (100 diabetic and 55 control) from 24~(th) September 2016 to 29~(th) March 2018. The corneal endothelial morphological features were evaluated using a non-contact EM-3000 specular microscope. The morphological characteristics of endothelial cell like the ECD, Coefficient of Variation (CV), Central Corneal Thickness (CCT), and percentage of hexagonal cells were compared between diabetic patients and the control population. Age, gender, blood pressure, duration of diabetes, fasting and Postprandial Blood Sugar (PPBS) HbA1c value, blood urea, and serum creatinine, Intra Ocular Pressure (IOP) were also recorded, and the endothelial cell characteristics were compared between the diabetic groups according to the duration (< or ≥ 3 years) and HbA1c% (< or ≥ 7%). An independent t-test was performed to compare the means of endothelial characteristics between study subjects and the control group and also between duration of diabetes and HbA1C levels. A p-value of less than 0.05 was considered statistically significant. The data were analysed using a SPSS statistical program.Results: Baseline characteristics like Fasting Blood Sugar (FBS), PPBS, HbA1c, Systolic and Diastolic Blood Pressure (SBP and DBP) were significantly higher in diabetic group than control. A significant difference in corneal thickness (p=0.01) and hexagonality (p<0.001) were also observed between both the groups. The diabetic group showed a reduction in cell density and a higher coefficient variation of cell size however the differences were not statistically significant, There was no significant difference in the ECD, CCT, CV, and hexagonality concerning to HbA1c level and duration of diabetes.Conclusion: Patients with diabetes had a significant increase in corneal thickness, and a higher frequency of pleomorphism compared to control subjects. In terms of ECD and co-efficient variation, no difference was observed between groups.
机译：角膜损伤是影响70％糖尿病患者的常见问题。糖尿病角膜具有功能异常，如角膜内皮细胞密度（ECD）降低，较厚的玉米体，具有增加的内皮渗透性，较小的角膜敏感性和升高的角膜自动荧光。目的：研究糖尿病患者的角膜内皮特征确定与内皮损伤相关的因素，并基于糖尿病和血糖控制的持续时间比较角膜变化。材料和方法：在155名患者（100名糖尿病和55个对照）中进行了医院的横截面研究2016年9月24日至（Th）至2018年3月29日〜（Th）。使用非接触式EM-3000镜面显微镜评估角膜内皮形态学特征。在糖尿病患者和对照群体之间比较了ECD，变异系数（CV），中央角膜厚度（CCT），中央角膜厚度（CCT）和六边形细胞百分比的形态学特征。年龄，性别，血压，糖尿病持续时间，禁食和餐后血糖（PPBS）HBA1C值，血尿尿素和血清肌酐，内部压力（IOP）的血液压力（IOP），并在糖尿病组之间进行了内皮细胞特征根据持续时间（<或≥3岁）和HBA1C％（<或≥7％）。进行独立的T检验以比较研究受试者和对照组之间的内皮特征手段，以及糖尿病持续时间和HBA1C水平之间。 p值小于0.05被认为是统计学意义的。使用SPSS统计程序分析数据。结果：糖尿病组的空腹血糖（FBS），PPBS，HBA1C，收缩压和舒张压（SBP和DBP）的基线特性比对照显着高。在两个组之间也观察到角膜厚度（P = 0.01）和六偏见（P <0.001）的显着差异。糖尿病组表现出细胞密度的降低和细胞尺寸的较高系数变异，但差异没有统计学意义，ECD，CCT，CV和关于HBA1C水平和糖尿病持续时间没有显着差异。< B>结论：与对照受试者相比，糖尿病患者的角膜厚度显着增加，并且较高的多形态频率。就ECD和共同有效的变异而言，组之间没有观察到差异。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号