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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Subclinical Atherosclerosis and Atherogenic Index of Plasma in Lichen Planus PatientsA Comparative Cross-sectional Study
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Subclinical Atherosclerosis and Atherogenic Index of Plasma in Lichen Planus PatientsA Comparative Cross-sectional Study

机译：地衣直升机患者对比较横截面研究的亚临床动脉粥样硬化和血浆静脉粥样硬化指标

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Lichen Planus (LP) is an idiopathic and chronic inflammatory disease that affects the skin and the mucous membranes, and studies have proven its association with increased risk for Cardiovascular (CV) diseases. Subclinical atherosclerosis and Atherogenic Index of Plasma (AIP) are strong predictors of CV risk.Aim: The primary aim of this study was the evaluation of Common Carotid artery mean Intima-Media wall Thickness (CIMT) and AIP which are predictors of CV risk in patients with LP.Materials and Methods: Fifty patients with LP and fifty age, gender and Body Mass Index (BMI) matched healthy controls (from the general population without the disease) were included in the study. CIMT was measured using ultrasound. Lipid profile was calculated by biochemical analysis. AIP was calculated from lipid profile using validated formula. Data was analysed using SPSS version 16.0 software.Results: Compared to healthy controls, patients had significantly higher CIMT. A 28% of patients had subclinical atherosclerosis compared to 2% of controls (p<0.001). Dyslipidemia was detected in 42% of patients and only 10% of controls (p<0.001). AIP was significantly elevated in LP patients compared to controls (p<0.001). A 36% of patients had high CV risk according to AIP versus 8% of controls. The 80% of controls had low CV risk versus 48% of patients (p<0.001).Conclusion: LP patients were found to have increased CV risk. CIMT, lipid profile and AIP can serve as important diagnostic markers of CV risk. Educating the patients about such a risk will enable them to follow lifestyle modifications so as to prevent further complications and morbidity.
机译：地衣直升机（LP）是一种特发性和慢性炎症性疾病，影响皮肤和粘膜，并证明其与心血管（CV）疾病的风险增加的关系。亚临床动脉粥样硬化和血浆（AIP）的动脉粥样硬化指数是CV风险的强预测因子。目的：本研究的主要目的是评估常见的颈动脉的意味着内膜介质壁厚（CIMT）和AIP​​的预测LP患者的CV风险。材料和方法：第50例LP和50岁患者，性别和体重指数（BMI）匹配的健康对照（来自普通群体的情况下）纳入该研究。使用超声测量CIMT。通过生物化学分析计算脂质谱。使用验证公式从脂质谱计算AIP。使用SPSS版本16.0软件进行分析数据。结果：与健康对照相比，患者的CIMT显着更高。 28％的患者的亚临床动脉粥样硬化与2％的对照相比（P <0.001）。在42％的患者中检测到血脂多症，只有10％的对照（P <0.001）。与对照相比，LP患者的AIP显着升高（P <0.001）。 36％的患者根据AIP与8％的对照有高的CV风险。 80％的对照的CV风险低，48％的患者（P <0.001）。结论：LP患者被发现增加了Cv风险。 CIMT，脂质谱和AIP可以作为CV风险的重要诊断标志物。教育患者此类风险将使它们能够遵循生活方式修改，以防止进一步的并发症和发病率。

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