Utility of TP53 in Breast Carcinoma Immunophenotypes

Ria Jaggi; Samarth Shukla; Sourya Acharya; Sunita Vagha

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Utility of TP53 in Breast Carcinoma Immunophenotypes

机译：TP53在乳腺癌免疫胞间型的效用

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Breast cancer is a heterogeneous disease and has significant variability in presentation, treatment response, and prognosis.The management of carcinoma breast is currently based on immunophenotypes and TNM (Tumour Nodes Metastasis)staging. The aim of the study is to review the literature and to look for treatment guidelines of carcinoma breast, the role ofimmunophenotypes in treatment of carcinoma breast, TP53 mutation in breast cancer, and the relationship of TP53 mutationwith immunophenotypes, histological grade, efficacy of chemotherapy, and BRCA mutation. Pubmed database was researchedand a total of 510 articles were analysed. A total of one meta-analysis, one randomised controlled trial, one literature review, nineprospective studies, and three retrospective studies were included for further analysis. It was observed that TP53 mutation isassociated with poor overall survival. It was also found to be inversely associated with the Estrogen Receptor (ER) status and soit was seen more commonly in basal type and Her2/neu enriched breast cancer. There is a need for further studies to establishthe definite association between TP53 and immunophenotypes so that TP53 alone can be used as a guide for management incarcinoma breast at low resource centres.

机译：乳腺癌是一种异质疾病，具有显着的介绍，治疗反应和预后的可变性。癌乳腺癌的管理目前基于免疫蛋白酶型和TNM（肿瘤节点转移）分期。该研究的目的是审查文献，并寻找癌乳腺癌的治疗准则，在乳腺癌中治疗癌乳腺癌，TP53突变的角色，以及TP53突变的关系，组织学等级，化疗疗效的关系。和BRCA突变。 PubMed数据库已研究和分析了510篇文章。共有一个荟萃分析，一个随机对照试验，一个文献综述，九项图研究和三项回顾性研究进行进一步分析。观察到TP53突变与差的整体存活率相同。它也发现与雌激素受体（ER）状态相反，雌激素的状态，并且更常见于基础类型和HER2 / Neu富集的乳腺癌。需要进一步研究，以确定TP53和免疫蛋白型之间的明确关联，因此单独的TP53可以用作低资源中心管理方法乳腺癌的指导。

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《Journal of Clinical and Diagnostic Research》 |2020年第9期|共5页
作者
Ria Jaggi; Samarth Shukla; Sourya Acharya; Sunita Vagha;
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Basal type breast cancerBlood richardson gradeGuardian of the genomeHer2/neu enrichedLuminal A/BMolecular classificationOestrogen receptorProgesterone receptorTumour suppressor gene;

机译：基础型乳腺癌Blood Richardson Greadomeher2 / Neu Enrichedluminal A / Bmolecular Classifico雌激素抑制剂基因;

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1. The TP53 codon 72 polymorphism may affect the function of TP53 mutations in breast carcinomas but not in colorectal carcinomas. [J] . Langerod A, Bukholm IR, Bregard A, Cancer epidemiology, biomarkers and prevention: A publication of the American Association for Cancer Research . 2002,第12期

机译：TP53密码子72多态性可能会影响乳腺癌中TP53突变的功能，但不会影响结直肠癌。
2. The breast cancer immunophenotype of TP53-p.R337H carriers is different from that observed among other pathogenic TP53 mutation carriers [J] . Fitarelli-Kiehl Mariana, Giacomazzi Juliana, Santos-Silva Patricia, Familial cancer . 2015,第2期

机译：TP53-p.R337H携带者的乳腺癌免疫表型与其他致病性TP53突变携带者中观察到的不同
3. Most basal-like breast carcinomas demonstrate the same Rb-/p16+ immunophenotype as the HPV-related poorly differentiated squamous cell carcinomas which they resemble morphologically. [J] . Subhawong AP, Subhawong T, Nassar H, American Journal of Surgical Pathology . 2009,第2期

机译：大多数基底样乳腺癌表现出与HPV相关的低分化鳞状细胞癌相同的Rb- / p16 +免疫表型，它们在形态上相似。
4. Correlation Analysis between PIK3CA, TP53, CDH1 Genes Mutations and Breast Cancer [C] . Dongyue Zhu, Yunjing Gu, Ping Zhu International Symposium on Distributed Computing and Applications for Business Engineering and Science . 2018

机译：PIK3CA，TP53，CDH1基因突变与乳腺癌的相关性分析
5. Oncomorphic TP53 mutations in advanced serous ovarian carcinomas. [D] . Brachova, Pavla. 2014

机译：晚期浆液性卵巢癌的同型TP53突变。
6. Most Basal-like Breast Carcinomas Demonstrate the Same Rb−/p16+ Immunophenotype as the HPV-related Poorly Differentiated Squamous Cell Carcinomas Which They Resemble Morphologically [O] . Andrea Proctor Subhawong, Ty Subhawong, Hind Nassar, -1

机译：大多数基底样乳腺癌表现出与形态相似的HPV相关的鳞状上皮细胞癌相关的Rb- / p16 +免疫表型。
7. Establishment and characterization of three stable Basal/HER2-positive breast cancer cell lines derived from Chinese breast carcinoma with identical missense mutations in the DNA-binding domain of TP53 [O] . Fei Zhou, Yanhua Zhang, Xiufang Xu, 2018

机译：三种稳定基底/海绵/海绵乳腺癌细胞系的建立与表征来自TP53的DNA结合结构域中具有相同畸变突变的乳腺癌

Utility of TP53 in Breast Carcinoma Immunophenotypes

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