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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Study of Glycation of Transferrin and its Effect on Biomarkers of Iron Status in Uncontrolled Diabetes Mellitus Patients
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Study of Glycation of Transferrin and its Effect on Biomarkers of Iron Status in Uncontrolled Diabetes Mellitus Patients

机译：转铁蛋白糖化的研究及其对不受控制的糖尿病患者的铁状况生物标志物的影响

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Diabetes Mellitus (DM) is a metabolic condition linked by the inability to produce enough insulin and/or to respond to insulin. This can lead to a number of acute and chronic health problems. In erythrocytes, transferrin is the main source of iron. Alterations in transferrin glycation affect transferrin saturation because the affinity of transferrin for Fe~(3+) is extremely high but it decreases progressively with increasing glycation.Aim: To investigate the influence of uncontrolled diabetes on transferrin glycation, iron metabolism and status.Materials and Methods: A total of 136 samples from 3 groups of HbA1c levels ( 8-uncontrolled DM) were studied for the correlation pattern of iron with other variables. Chi square test and student’s t-test were performed to reveal the association between serum free iron levels and other variables with DM.Results: Serum iron has shown to be depleted significantly (p=0.02) along with percentage saturation (p=0.0006) with increase in diabetic severity. No significant differences were observed in serum ferritin in controlled DM and uncontrolled samples. Total Iron Binding Capacity (TIBC) was found to be significantly increased in uncontrolled DM samples (p=0.01). Abnormal transferrin was observed uncontrolled diabetes with subsequent depletion in transferrin, which in turn results in low serum iron, lower percentage saturation and high TIBC.Conclusion: Uncontrolled diabetes affects the glycation of transferrin also thus perturbating iron metabolism. This study emphasises the need to monitor transferrin glycation status and iron deficiency anaemia in subjects with uncontrolled diabetes.
机译：糖尿病（DM）是通过不能产生足够的胰岛素和/或响应胰岛素的代谢条件。这可能导致许多急性和慢性健康问题。在红细胞中，转铁蛋白是铁的主要来源。转铁蛋白糖化的改变影响转移素饱和度，因为转铁蛋白的Fe〜（3+）的亲和力非常高，但随着糖化的增加，它逐渐减少。目的：探讨不受控制的糖尿病对转铁蛋白糖蛋白的影响，铁代谢和地位。材料和方法：研究了来自3组HBA1C水平（8-不受控制DM）的总共136个样品，用于与其他变量的熨斗相关图案。进行Chi Square测试和学生的T检验以揭示血清自由铁水平和其他变量与DM之间的关联。结果：血清铁已经显着耗尽（p = 0.02）以及百分比饱和度（p = 0.0006）增加糖尿病严重程度。在受控DM和不受控制的样品中，在血清铁蛋白中没有观察到显着差异。发现总铁结合能力（TIBC）在不受控制的DM样品中显着增加（P = 0.01）。观察到异常的转移素，随后在转化素中耗尽，这反过来导致低血清铁，较低的饱和度和高TIBC。结论：不受控制的糖尿病影响转铁蛋白的糖蛋白也会扰动铁代谢。本研究强调需要在具有不受控制的糖尿病的受试者中监测转铁蛋白糖化状态和缺铁性贫血。

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