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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Efficacy of Carica Papaya Leaf Extract in Reducing Treatment-Delay Secondary to Chemotherapy induced Thrombocytopenia
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Efficacy of Carica Papaya Leaf Extract in Reducing Treatment-Delay Secondary to Chemotherapy induced Thrombocytopenia

机译：Carica番木瓜叶提取物在减少治疗 - 诱导血小板减少血小板减少治疗延迟的疗效

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Chemotherapy Induced Thrombocytopenia (CIT) is a common problem in clinical oncology. It leads to delay in administration of chemotherapy resulting in inferior outcomes. Timely administration of chemotherapy is necessary to ensure maximal benefits to the patient.Aim: This study was carried out to assess the efficacy of Carica Papaya Leaf Extract (CPLE) in reducing the delay in administration of chemotherapy.Materials and Methods: This was a retrospective single centre study conducted at Amrita Institute of Medical Sciences, Kochi, Kerala from July to December 2018. Fifty events of chemotherapy induced thrombocytopenia in forty five patients with proven malignancy were assessed for therapeutic response to standard doses of CPLE. Wilcoxon signed rank test and Karl Pearsona??s correlation coefficient was applied to test the statistical significance in mean values from baseline to follow-up period and to obtain correlation between continuous variables respectively.Results: There was a significant improvement in the platelet count in 54% (n=27) patients within 5 days and another 16% (n=8) by 7 days of CPLE administration. The 18% (n=9) patients took longer than one week to recover their platelet counts. The 12% (n=6) patients had deteriorating platelet counts even after CPLE intervention, one among them mandating platelets transfusion.
机译：化疗诱导血小板减少症（CIT）是临床肿瘤学中的常见问题。它导致化疗延迟导致劣质结果。需要及时施用化疗，以确保对患者的最大益处。目的：本研究进行了评估Carica番木瓜叶提取物（COL）在降低化疗施用延迟时的疗效。材料和材料方法：这是在2018年7月至2018年12月的喀拉拉州亚历·医学研究所开展的回顾性单一中心研究，从2018年至12月开始。评估了第四十五名患者的50例化疗诱导血小板症的血小板减少患者的治疗反应对标准剂量。 Wilcoxon签名等级测试和Karl Pearsona的相关系数用于测试从基线到随访时间的平均值的统计显着性，并分别获得连续变量之间的相关性。结果：效果显着改善血小板计数在54％（n = 27）患者的5天内，另外16％（n = 8）含量为7天。 18％（n = 9）患者花了超过一周的时间来恢复血小板计数。 12％（n = 6）患者甚至在血液干预后血小板计数甚至均授权血小板输血中的一个。

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