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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Microbiological Analysis of Skin and Soft Tissue Infections and their Antibiogram in a Tertiary Care Teaching Hospital in Mumbai, India
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Microbiological Analysis of Skin and Soft Tissue Infections and their Antibiogram in a Tertiary Care Teaching Hospital in Mumbai, India

机译:印度孟买三级护理教学医院皮肤和软组织感染的微生物分析及其抗诊断

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Wound infections, an important cause of morbidity and mortality are associated with longer hospital stay resulting in increased cost on healthcare system. Studies on pus or wound culture can guide the clinicians to select the proper antibiotic which can reduce the development of resistance due to improper antibiotic usage.Aim: To study the microbiological profile and antimicrobial susceptibility pattern of various isolates obtained from wounds, abscesses, tissues, and tissue aspirates in a tertiary care teaching hospital.Materials and Methods: This was a retrospective study conducted in the Department of Microbiology over a period of one year, from January to December 2017. Data were collected from the records, on a total of 880 samples received from various wards, ICU and OPD. As per the hospital protocol, they were processed aerobically using the standard microbiological culture techniques. Statistical analysis was done by counts and percentages using MS Excel version 2010.Results: During study period, out of total 880 samples, 574 (65.23%) samples were positive for growth. Out of 574 samples, 38 (6.62%) showed polymicrobial growth. The total number of isolates was 612 (69.54%) in which 375 (61.27%) were gram negative bacteria, 233 (38.07%) were gram positive bacteria whereas, 04 (0.65%) were fungal isolates. Overall the most common bacterial organism was Staphylococcus aureus 134 (22.04%). Among gram negative bacteria, the most common isolate was Pseudomonas aeruginosa 110 (29.33%) whereas, MSSA 75 (32.19%) predominated among the gram positive bacteria. All 4 (100%) fungal isolates were non-albicans Candida species. All Gram positive isolates were sensitive to Vancomycin (100%) and Linezolid (100%). The antibiotic sensitivity of the Pseudomonas aeruginosa displayed that majority of them were sensitive to Meropenem 85 (77.27%) and Piperacillin-Tazobactum 72 (65.45%).Conclusion: The most common pathogen isolated was Staphylococcus aureus. All gram positive isolates were sensitive to Vancomycin and Linezolid. Hence, Vancomycin and Linezolid were the most promising drugs against gram positive bacteria. The most common gram negative pathogen was Pseudomonas aeruginosa and the majority of them were sensitive to Meropenem and Piperacillin-Tazobactum.
机译:伤口感染,发病率和死亡率的重要原因与较长的医院住宿有关,导致医疗保健系统的成本增加。脓液或伤口培养的研究可以指导临床医生选择适当的抗生素,这可以降低由于抗生素使用不当导致的抵抗力的发展。目的:研究从伤口,脓肿获得的各种分离物的微生物曲线和抗微生物敏感性模式,组织和组织在第三级护理教学医院中的吸气。材料和方法:这是从2017年1月到12月的微生物学系进行的回顾性研究。从记录中收集数据总共从各个病房,ICU和OPD收到的880个样本。根据医院方案,它们使用标准的微生物培养技术满足于各种处理。使用MS Excel版本2010的计数和百分比进行统计分析。结果:在研究期间,总共880个样品中,574(65.23%)样品为生长阳性。在574个样品中,38例(6.62%)显示出多种状体生长。分离株总数为612(69.54%),其中375(61.27%)是革兰氏阴性细菌,233(38.07%)是革兰氏阳性细菌,而04(0.65%)是真菌分离株。总体而言,最常见的细菌生物是金黄色葡萄球菌134(22.04%)。在革兰氏阴性细菌中,最常见的分离物是假单胞菌铜绿假单胞菌110(29.33%),而MSSA 75(32.19%)以革兰氏阳性细菌占主导地位。所有4(100%)真菌分离物是非蛋白质人的念珠菌物种。所有克阳性分离物对万古霉素(100%)和LINZOLID(100%)敏感。假单胞菌铜绿假单胞菌的抗生素敏感性显示出它们的大部分对梅洛克西姆85(77.27%)和Piperacillin-tazobactum 72(65.45%)敏感。结论:分离的最常见的病原体是金黄色葡萄球菌。所有克阳性分离株对万古霉素和线唑氏菌素敏感。因此,万古霉素和LINEzolid是对革兰氏阳性细菌最有前途的药物。最常见的革兰氏阴性病原体是假单胞菌铜绿假单胞菌,其中大部分对梅洛克西姆和哌啶-Tazobactum敏感。

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