The antimicrobial activity of lactic acid bacteria is closely related to its metabolites. Our results showed that Lactobacillus plantarum DY‐6 had the highest antibacterial activities among the seven bacteria tested in this study. To fully understand the active antimicrobial substances in L.?plantarum DY‐6, the cell‐free supernatant (CFS) were analyzed. Our data indicated that the antibacterial effect of the CFS was positively correlated with the growth of the bacteria, and the main antibacterial substances were lactic acid, acetic acid, propionic acid, caprylic acid, and decyl acid. Finally, this study demonstrated that the antibacterial active substance produced by the lactic acid bacteria could destroy the cell membrane structure of the bacteria, causing bacteria to fail to grow and reproduce normally, thereby exerting a bacteriostatic action. Taken together, our current findings would provide an effective method for rapid screening of antimicrobial substances.
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机译：乳酸菌的抗微生物活性与其代谢物密切相关。我们的研究结果表明，在本研究中测试的七种细菌中，Lactobacillus Plantarum Dy-6具有最高的抗菌活性。为了完全理解L.?Plantarum Dy-6中的活性抗微生物物质，分析无细胞上清液（CFS）。我们的数据表明，CFS的抗菌效果与细菌的生长呈正相关，主要抗菌物质是乳酸，乙酸，丙酸，毛酸和癸酸。最后，本研究证明，乳酸菌产生的抗菌活性物质可能破坏细菌的细胞膜结构，导致细菌不能正常生长和再现，从而施加抑菌作用。我们目前的发现将提供一种有效的方法，用于快速筛选抗微生物物质。
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