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Revealing fine-scale spatiotemporal differences in SARS-CoV-2 introduction and spread

机译：揭示SARS-COV-2引入和传播的细尺时空差异

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Evidence-based public health approaches that minimize the introduction and spread of new SARS-CoV-2 transmission clusters are urgently needed in the United States and other countries struggling with expanding epidemics. Here we analyze 247 full-genome SARS-CoV-2 sequences from two nearby communities in Wisconsin, USA, and find surprisingly distinct patterns of viral spread. Dane County had the 12th known introduction of SARS-CoV-2 in the United States, but this did not lead to descendant community spread. Instead, the Dane County outbreak was seeded by multiple later introductions, followed by limited community spread. In contrast, relatively few introductions in Milwaukee County led to extensive community spread. We present evidence for reduced viral spread in both counties following the statewide “Safer at Home” order, which went into effect 25 March 2020. Our results suggest patterns of SARS-CoV-2 transmission may vary substantially even in nearby communities. Understanding these local patterns will enable better targeting of public health interventions. In this study, the authors present an analysis of 247 full-genome SARS-CoV-2 sequences obtained from two communities in Wisconsin, USA, and report distinct patterns of viral spread. Their results suggest that patterns of SARS-CoV-2 transmission and spread may vary substantially, even between neighbouring communities.
机译：最大限度地减少新SARS-COV-2传输集群引入和传播的循证公共卫生方法在美国和其他国家努力扩大流行病的国家。在这里，我们分析了美国威斯康星州威斯康辛的两个附近社区的247个全基因组SAR-COV-2序列，并发现了令人惊讶的病毒传播模式。 Dane County在美国的第12次已知的SARS-COV-2引入，但这并没有导致后裔社区传播。相反，Dane County爆发被多次后来介绍，其次是有限的社区传播。相比之下，密尔沃基县的介绍相对较少地导致广泛的社区传播。我们提出了在州际遍布的“家中”秩序之后的两次县中的病毒扩散的证据，该秩序进入了2020年3月25日。我们的结果表明SARS-COV-2变速器的模式可能会在附近的社区中显着变化。了解这些本地模式将使公共卫生干预措施更好地瞄准公共卫生干预措施。在这项研究中，作者呈现了从威斯康星州，美国的两个社区获得的247个全基因组SAR-COV-2序列，并报告了鲜明的病毒蔓延模式。它们的结果表明，即使在邻近的社区之间，SARS-COV-2传输和涂抹模式也可能变化。

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