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首页> 外文期刊>African journal of urology >Evaluation of androgen receptor status in urothelial carcinoma of the urinary bladder in Egyptian patients: an immunohistochemical study
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Evaluation of androgen receptor status in urothelial carcinoma of the urinary bladder in Egyptian patients: an immunohistochemical study

机译：埃及患者尿潴留尿路脉癌雄激素受体状态评价：免疫组化研究

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Background:The roles of androgen and androgen receptor (AR) signaling in the oncogenesis of prostate cancer are very well established. What is more poorly understood is the role of AR in other human malignancies including bladder cancer. The incidence of bladder cancer is much higher in males than females, but the exact etiology has not been fully elucidated. This gender disparity has raised the possibility of the AR pathway being involved in the genesis of this disease. Thereby, the aim of this work was to evaluate the expression of AR in a group of Egyptian patients with urothelial bladder carcinoma and to assess whether its expression was correlated with other pathological tumor features. Urothelial bladder carcinoma tissue samples from 50 patients were studied by immunostaining for AR expression in tumor cells.ResultsAR was positively expressed in 29 (58%) patients, while negative expression was observed in 21 (42%) patients. No statistically significant difference in AR expression with respect to tumor grade (P?=?0.07) and pT stage (P?=?0.09) was observed.ConclusionsThe results obtained in this study indicates a clinical value of the AR expression in Egyptian patients with urothelial bladder carcinoma, providing the basis for further studies to evaluate its role and the possibility of new target-based therapies for urothelial bladder carcinoma.
机译：背景：雄激素和雄激素受体（AR）信号传导在前列腺癌的血管生成中的作用非常成立。更难以理解的是AR在包括膀胱癌等其他人类恶性肿瘤中的作用。膀胱癌的发病率比女性高得多，但确切的病因尚未完全阐明。这种性别差异提出了AR途径参与该疾病的成因的可能性。因此，这项工作的目的是评估一组埃及膀胱癌患者的AR的表达，并评估其表达是否与其他病理肿瘤特征相关。通过在肿瘤细胞中的AR表达中进行50例患者的尿路瓶膀胱癌组织样本。患者在29例（58％）患者中呈正表达，而在21例（42％）患者中观察到阴性表达。观察到肿瘤级（ p α=Δ=Δ= 0.07）和pt阶段（ p Δ=Δse09）的统计学上没有统计学意义。结论结果本研究表明埃及尿路上膀胱癌患者的AR表达的临床价值，为进一步研究提供了评价其作用的基础和尿路上膀胱癌的新靶标疗法的可能性。

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