首页> 外国专利> pharmaceutically acceptable salt or compound thereof, pharmaceutical composition, methods for reducing the calcium conductance of a cellular capsaicin receptor, and for inhibiting the binding of vanilloid ligand to a capsaicin receptor, method for treating a condition responsive to receptor modulation. capsaicin, pain, itching, cough or hiccup and urinary incontinence or overactive bladder in a patient, methods to promote weight loss in an obese patient, to identify a capsaicin receptor binding agent, and to determine the presence or absence of capsaicin receptor in a sample, conditioned pharmaceutical preparation, and use of compound or salt

pharmaceutically acceptable salt or compound thereof, pharmaceutical composition, methods for reducing the calcium conductance of a cellular capsaicin receptor, and for inhibiting the binding of vanilloid ligand to a capsaicin receptor, method for treating a condition responsive to receptor modulation. capsaicin, pain, itching, cough or hiccup and urinary incontinence or overactive bladder in a patient, methods to promote weight loss in an obese patient, to identify a capsaicin receptor binding agent, and to determine the presence or absence of capsaicin receptor in a sample, conditioned pharmaceutical preparation, and use of compound or salt

机译:药学上可接受的盐或其化合物,药物组合物,降低细胞辣椒素受体的钙电导和抑制香草素配体与辣椒素受体结合的方法,治疗对受体调节有反应的疾病的方法。辣椒素,患者的疼痛,瘙痒,咳嗽或打h和尿失禁或膀胱过度活动症,促进肥胖患者体重减轻,鉴定辣椒素受体结合剂并确定样品中是否存在辣椒素受体的方法,调理药物制剂以及化合物或盐的用途

摘要

PHARMACEUTICALLY ACCEPTABLE COMPOUND OR SALT OF THE SAME PHARMACEUTICAL COMPOSITION METHODS TO REDUCE THE CALCIUM CONDUCTANCE OF A CELL CAPSAIC RECEIVER, AND TO INHIBIT THE CONNECTION OF THE RECANDIENT CABLE RECEPTIN CABLE RECEPTOR , PAIN, ITCHING, CUSHING OR SOLUTION AND URINARY INCONTINENCE OR SUPERATORY BLADDER IN A PATIENT, METHODS TO PROMOTE LOSS OF WEIGHT IN AN OBESE PATIENT, TO IDENTIFY AN AGENT CONNECTIVE TO THE CAPSAICINE RECEIVER OR DETERMINATION CAPSAICIN IN A SAMPLE, PACKAGED PHARMACEUTICAL PREPARATION, AND USE OF COMPOUND OR SALT Substituted biaryl piperazinyl pyridine analogs are provided with formula (I): wherein the variables are as described herein. These compounds are ligands that can be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in treating conditions associated with pathological receptor activation in humans, domesticated pets and farm animals. Pharmaceutical compositions and methods for using these compounds to treat these disorders are provided, as are methods for using these ligands for receptor localization studies.
机译:相同药物成分方法的药物可接受的化合物或盐,以降低细胞电容接收器的钙电导率,并阻止可重复电缆接收器电缆接收器,针,插入,插入或接缝的插入,插入或插入病人,在肥胖患者中促进体重减轻,鉴定与可卡因的受体或测定辣椒素有关的药物的方法,包装的药物制备方法以及与化合物或盐取代的化合物的使用方法):其中变量如此处所述。这些化合物是可用于在体内或体外调节特异性受体活性的配体,并且在治疗与人类,家养宠物和农场动物中的病理性受体活化有关的病症中特别有用。提供了使用这些化合物治疗这些疾病的药物组合物和方法,以及使用这些配体进行受体定位研究的方法。

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