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首页> 外文期刊>Gastroenterology Insights >Ventilatory Effect of Midazolam in Propofol Deep Sedation for Hepatic Tumor Patients Undergoing Percutaneous Radiofrequency Ablation Procedure
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Ventilatory Effect of Midazolam in Propofol Deep Sedation for Hepatic Tumor Patients Undergoing Percutaneous Radiofrequency Ablation Procedure

机译：咪达唑仑在经皮射频消融术后肝肿瘤患者的异丙醇深镇静作用

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Objective: The aim of the study was to compare the ventilatory effect between propofol deep sedation technique with and without midazolam in hepatic tumor patients undergoing radiofrequency ablation procedure. Methods: Three hundred and seventy-four patients who underwent radiofrequency ablation procedure in a single year were randomly assigned to the deep sedation without midazolam group (A, n = 187) and deep sedation with midazolam group (B, n = 187). Patients in group A received normal saline, and those in group B received 0.02 mg/kg of midazolam intravenously in equivalent volume. All patients were oxygenated with 100% O2 via nasal cannula and sedated with intravenous fentanyl and the titration of intravenous propofol. Ventilatory parameters, including oxygen saturation, end tidal carbon dioxide, and respiratory rate every five minutes, during and after the procedure, as well as the duration of sleep and sedation score in the recovery room, were recorded. Results: There were no significant differences in the patients’ characteristics, duration of procedure, total dose of propofol, ventilatory parameters including oxygen saturation, end tidal carbon dioxide, and respiratory rate, as well as sedation score at 20, 25, 30, 35, and 40 min after the procedure, between the two groups. However, mean sedation score at 5, 10, and 15 min after the procedure, in group B, was significantly lower than in group A. In addition, the duration of sleep after the procedure, in group B, was significantly greater than in group A. No serious ventilatory adverse effects were observed either group. Conclusion: Propofol deep sedation with and without midazolam for hepatic tumor patients who underwent radiofrequency ablation procedure was safe and effective. A low dose of midazolam in propofol deep-sedation technique did not create serious ventilatory effects.
机译：目的：该研究的目的是在肝脏肿瘤患者接受射频消融程序的肝脏肿瘤患者中比较异丙酚深镇静技术之间的逆向效应。方法：三百七十四名患者在一年内接受射频消融程序的患者被随机分配给没有咪达唑仑组（A，N = 187）的深镇静，占咪达唑仑组（B，N = 187）的深镇静。 A组患者接受的正常盐水，B组中的那些在等效体积中静脉内接受0.02mg / kg咪达唑仑。所有患者通过鼻腔套管用100％O 2氧化氧化，并用静脉内芬太尼和静脉内异丙酚的滴定。透气参数，包括氧饱和度，最终潮汐二氧化碳和呼吸速率每五分钟，过程中和之后的过程，以及恢复室中的睡眠和镇静分数的持续时间。结果：患者的特点，程序持续时间，血红蛋白总剂量，通气参数，包括氧饱和，末端潮汐二氧化碳和呼吸率，以及呼吸速度，以及镇静分数，以及镇静分数，以及20,25,30，35，35在两组之间的过程后40分钟。然而，在B组中，在第B组后5,10和15分钟的平均镇静评分显着低于A组。此外，在B组后睡眠的持续时间明显大于组A.无论是群体都没有观察到严重的透气不良反应。结论：Healofol Deazation and Histazolam用于接受射频消融程序的肝脏肿瘤患者是安全有效的。双溴酚深镇静技术中的低剂量咪达唑仑没有产生严重的透气效应。

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