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The Application of Bioreactors for Cartilage Tissue Engineering: Advances, Limitations, and Future Perspectives

机译:生物反应器对软骨组织工程的应用:进步,限制和未来的观点

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Tissue engineering (TE) has brought new hope for articular cartilage regeneration, as TE can provide structural and functional substitutes for native tissues. The basic elements of TE involve scaffolds, seeded cells, and biochemical and biomechanical stimuli. However, there are some limitations of TE; what most important is that static cell culture on scaffolds cannot simulate the physiological environment required for the development of natural cartilage. Recently, bioreactors have been used to simulate the physical and mechanical environment during the development of articular cartilage. This review aims to provide an overview of the concepts, categories, and applications of bioreactors for cartilage TE with emphasis on the design of various bioreactor systems.
机译:组织工程(TE)为关节软骨再生带来了新的希望,因为TE可以为原生组织提供结构和功能替代品。 TE的基本元素涉及支架,种子细胞和生物化学和生物力学刺激。 但是,TE有一些局限性; 最重要的是,支架上的静态细胞培养不能模拟天然软骨发展所需的生理环境。 最近,生物反应器已被用来模拟关节软骨开发过程中的物理和机械环境。 该审查旨在概述软骨TE的生物反应器的概念,分类和应用,重点是各种生物反应器系统的设计。

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