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首页> 外文期刊>Stem cells international >Therapeutic Study of Thermosensitive Hydrogel Loaded with Super-Activated Platelet Lysate Combined with Core Decompression Technology for the Treatment of Femoral Head Necrosis
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Therapeutic Study of Thermosensitive Hydrogel Loaded with Super-Activated Platelet Lysate Combined with Core Decompression Technology for the Treatment of Femoral Head Necrosis

机译：具有超激活血小板裂解物的热敏水凝胶的治疗研究与核心减压技术相结合治疗股骨头坏死

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摘要

Super activated platelet lysate (sPL) is a derivative of platelet-rich plasma (PRP) that contains high levels of several growth factors. In this study, we synthesized a temperature-sensitive hydrogel that contained temperature-sensitive Poly(DL-lactide-glycolide-glycolide acid) (PLGA), SrCl 2 , and HA, and loaded it with different concentrations of sPL. The hydrogel showed satisfactory encapsulation efficiency and release of the growth factors in a sustained manner, indicating its suitability as a drug carrier. The sPL-loaded hydrogel was inserted into the necrotic femoral head of a rat model and core decompression was applied and resulted in significantly accelerated bone repair and regeneration. Therefore, encapsulation of sPL in a hydrogel scaffolding may be an effective strategy for treating femoral head necrosis.
机译：超活性血小板裂解物（SPL）是富含血小板的血浆（PRP）的衍生物，其含有高水平的几种生长因子。 在该研究中，我们合成了一种温度敏感的水凝胶，其含有温度敏感的聚（DL-丙交酯 - 乙二醇酰乙酰甲酸）（PLGA），SrCl 2和Ha，并用不同浓度的SPL加载它。 水凝胶以持续的方式显示出令人满意的封装效率和生长因子的释放，表明其作为药物载体的适用性。 将载荷的水凝胶插入到大鼠模型的坏死股头中，并施加核心减压，导致骨修复和再生显着加速。 因此，水凝胶支架中的SPL封装可以是治疗股骨头坏死的有效策略。

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