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首页> 外文期刊>Journal of oncology >The Prognostic Value of Log Odds of Positive Lymph Nodes in Early-Stage Esophageal Cancer Patients: A Study Based on the SEER Database and a Chinese Cohort
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The Prognostic Value of Log Odds of Positive Lymph Nodes in Early-Stage Esophageal Cancer Patients: A Study Based on the SEER Database and a Chinese Cohort

机译：早期食管癌患者阳性淋巴结程少数的预后价值：基于SEER数据库和中国队列的研究

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Objective . Early detection and timely treatment are important for improving the prognosis of esophageal cancer (EC). Identification of the prognostic risk factors could help us to discern the high-risk population. This study was aimed at exploring the prognostic significance of log odds of positive lymph nodes (LODDS) in early-stage EC patients. Methods . Patients who underwent esophagectomy and diagnosed as pathologic T1-2 N0 EC were reviewed between January 2005 and December 2015 from the Surveillance, Epidemiology, and End Results (SEER) database (the development cohort, n ?=?1004). The X-tile software was used to determine the optimal cutoff values of LODDS. A separate Chinese cohort including 245 patients (the validation cohort) was used to externally validate the results of the SEER database. Result . Patients were divided into two groups based on the cutoff points of LODDS: ). In multivariate Cox analysis, LODDS was associated with OS significantly (hazard ratio (HR), 1.48; 95% confidence intervals (CI), 1.19–1.85). In the validation cohort, the 5-year OS rate was 76.6% for patients in the LODDS1 group, compared with 64.4% for those in the LODDS2 group ( ). The HR value in multivariate Cox analysis for OS was 2.00 (95% CI, 1.26–3.18). Conclusion . LODDS was an important independent factor for survival in early-stage EC patients.
机译：客观的 。早期检测和及时治疗对于改善食管癌的预后（EC）是重要的。鉴定预后风险因素可以帮助我们辨别高风险的人群。本研究旨在探讨早期EC患者阳性淋巴结（LODDS）对数量的预后意义。方法 。从监测，流行病学和最终结果（SEER）数据库（开发队列，N？= 1004），从2005年和2015年12月审查了接受食道切除术和诊断为病态T1-2 N0 EC的患者。 X-Tile软件用于确定Lodds的最佳截止值。单独的中文群组包括245名患者（验证队队）用于外部验证SER数据库的结果。结果 。患者基于Lodds的截止点分为两组:)。在多变量COX分析中，宿老性与OS显着相关（危险比（HR），1.48; 95％置信区间（CI），1.19-1.85）。在验证队列中，Lodds1组的患者为5年的OS率为76.6％，而Lodds2组（）中的患者则为64.4％。 OS的多变量COX分析中的HR值为2.00（95％CI，1.26-3.18）。结论 。宿冻是早期EC患者存活的重要独立因素。

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