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首页> 外文期刊>Infection and immunity >Granulocyte-macrophage colony-stimulating factor: involvement in control of Trypanosoma cruzi infection in mice.
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Granulocyte-macrophage colony-stimulating factor: involvement in control of Trypanosoma cruzi infection in mice.

机译：粒细胞 - 巨噬细胞殖民地刺激因子：涉及对小鼠进行锥虫瘤菌感染的涉及。

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Several cytokines play crucial roles in Trypanosoma cruzi infection in mice, but the involvement of endogenous granulocyte-macrophage colony-stimulating factor (GM-CSF) is poorly documented. This report shows that T. cruzi infection of mice triggered an early and sharp increase in plasma GM-CSF during the ascending phase of parasitemia. The plasma GM-CSF concentration remained stable at the peak of parasitemia and subsequently increased in those mice that survived to the acute phase. GM-CSF level increased again sharply, while parasitemia was rapidly decreasing. Finally, GM-CSF was undetectable, soon after the disappearance of circulating parasites. Injection of T. cruzi-infected mice with neutralizing anti-GM-CSF monoclonal antibodies induced the early appearance of parasitemia and aggravated cumulative mortality. In contrast, recombinant mouse GM-CSF (rmGM-CSF) caused sharp decreases in both parasitemia and cumulative mortality in T. cruzi-infected mice. Peritoneal macrophages from rmGM-CSF-treated and infected or uninfected mice were less infected ex vivo than those from control mice. Taken together these data demonstrate the protective action of endogenous GM-CSF in T. cruzi infection. Neutralization of endogenous GM-CSF aggravates infection, while exogenous rmGM-CSF decreases both parasitemia and host mortality.
机译：几种细胞因子在小鼠中睾丸瘤感染中起关键作用，但内源性粒细胞 - 巨噬细胞菌落刺激因子（GM-CSF）的累及记录不佳。本报告显示，在寄生虫的上升期间，小鼠的Cruzi感染在血浆阶段引发了血浆GM-CSF的早期和急剧增加。血浆GM-CSF浓度保持稳定在寄生虫的峰值中，随后在那些恢复到急性期的小鼠中增加。 GM-CSF水平急剧增加，而寄生虫迅速下降。最后，在循环寄生虫消失后，GM-CSF不可检测。用中和抗GM-CSF单克隆抗体注射T.Cruzi感染的小鼠诱导寄生症早期出现并加剧累积死亡率。相比之下，重组小鼠GM-CSF（RMGM-CSF）导致寄生虫血症和克鲁兹受感染的小鼠的累积死亡率急剧下降。来自RMGM-CSF治疗和感染或未感染的小鼠的腹膜巨噬细胞比来自对照小鼠的小鼠的小鼠更少。占据这些数据，证明了内源性GM-CSF在T.Cruzi感染中的保护作用。内源性GM-CSF的中和加剧感染，而外源性RMGM-CSF降低寄生虫和宿主死亡率。

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