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首页> 外文期刊>Journal of Clinical Microbiology >Endemic Genotypes of Candida albicans Causing Fungemia Are Frequent in the Hospital
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Endemic Genotypes of Candida albicans Causing Fungemia Are Frequent in the Hospital

机译：念珠菌念珠菌的流动基因型在医院常常常见

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Genotyping of Candida albicans strains causing candidemia can uncover the presence of endemic genotypes in the hospital. Using a highly reproducible and discriminatory microsatellite marker panel, we studied the genetic diversity of 217 C. albicans isolates from the blood cultures of 202 patients with candidemia (from January 2007 to December 2011). Each isolate represented 1 candidemia episode. Multiple episodes were defined as the isolation of C. albicans in further blood cultures taken ≥7 days after the last isolation in blood culture. Of the 202 patients, 188 had 1 episode, 13 had 2 episodes, and 1 had 3 episodes. Identical genotypes showed the same alleles for all 6 markers. The genotypes causing both episodes were identical in most patients with 2 episodes (11/13; 84.6%). In contrast, 2 different genotypes were found in the patient with 3 episodes, one causing the first and second episodes and the other causing the third episode (isolated 6 months later). We found marked genetic diversity in 174 different genotypes: 155 were unique, and 19 were endemic and formed 19 clusters (2 to 6 patients per cluster). Up to 25% of the patients were infected by endemic genotypes that infected 2 or more different patients. Some of these endemic genotypes were found in the same unit of the hospital, mainly neonatology, whereas others infected patients in different wards.
机译：导致念珠菌的念珠菌菌株的基因分型可以在医院中揭示病情的存在性基因型存在。使用高度可重复和鉴别的微卫星标记面板，我们研究了217℃的遗传多样性来自202名念珠菌患者的血培养物（从2007年1月至2011年12月）的血液培养物。每种孤立都代表了1个候选血症一集。多次发作被定义为在血液培养的最后一次分离后≥7天的血液培养中的血液培养中的蛋白化合物的分离。在202名患者中，188名有1次，13个有2个发作，1个发作。相同的基因型显示所有6个标记的等位基因。导致两个发作的基因型在大多数患者中相同（11/13; 84.6％）。相比之下，在具有3个发作的患者中发现了2种不同的基因型，一种引起第一和第二发作以及另一个引起第三集（分离6个月后）。我们发现174种不同的基因型中标记的遗传多样性：155种是独特的，19例是流行的，形成19个簇（每簇2至6例患者）。高达25％的患者被感染了2例或更多患者的流动基因型感染。其中一些有条不绝的基因型在医院的同一单元中发现，主要是新生儿学，而其他病房则感染患者。

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