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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Study of Effect of Nd:YAG Capsulotomy on Corneal Endothelium: A Teaching Hospital Based Prospective study
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Study of Effect of Nd:YAG Capsulotomy on Corneal Endothelium: A Teaching Hospital Based Prospective study

机译：ND：YAG胶囊术对角膜内皮的影响研究：基于教学的前瞻性研究

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Posterior Capsular Opacification (PCO) is a condition which develops months or years after cataract surgery.The Neodymium Yttrium Aluminium Garnet (Nd:YAG) laser capsulotomy is the procedure of choice for PCO and its adverse effects include intraocular pressure elevation, cystoid macular oedema, corneal endothelial cell damage, retinal detachment and Intraocular Lens (IOL) pitting.Aim: To assess the corneal endothelial structure and function before and after Nd:YAG laser capsulotomy in patients with PCO using specular microscopy.Materials and Methods: This was a prospective observational study carried out in Bharati Vidyapeeth (Deemed to be University) Medical College and Hospital, Sangli, Maharashtra, India on 50 eyes of 50 patients having PCO.This study was conducted in the time period between October 2020 to February 2021 for four months.Patients were subjected to Nd:YAG laser capsulotomy in the affected eye and were followed-up at one week and one month postprocedure.Specular Microscopy was used to evaluate the Endothelial Cell Density (ECD), Coefficient of Variation (CV) and Hexagonality of endothelial cells before and after laser capsulotomy.Statistical Package for Social Sciences (SPSS) version 26.0 was used for the statistical analysis.Chisquare test and ANOVA test are the tests of significance applied in this study.Results: Forty-five patients (90%) gained Best Corrected Visual Acuity (BCVA) of >6/18 after one week and 47 patients (94%) gained BCVA of ≥6/18 after one month postprocedure.Mean ECD prelaser was 2356.76 cells/mm2 , which decreased to 2231.8 cells/mm2 at one week and 2199.2 cells/mm2 at one month follow-up.The difference between prelaser ECD and at one week and one month was 124.96 cells/mm2 and 157.56 cells/mm2 , respectively, which was statistically significant at one month (p<0.0001).The mean CV prelaser was 33.74, at one week was 35.58 and at one month it was 37.22.The difference in CV from prelaser status to one month was statistically significant (p<0.0001).The mean hexagonality at baseline was 65.34% which decreased to 62.02% at one week and 60.42% at one month follow-up.The difference in hexagonality between one month and baseline was statistically significant (p<0.0001).Conclusion: Nd:YAG laser capsulotomy is a safe, effective and non invasive method for the treatment of PCO.However, it causes structural and functional corneal endothelial cell damage.
机译：后葫芦透露型（PCO）是一种在白内障手术后发展月份或多年的病症。钇钇铝石榴石（ND：YAG）激光涂层术是PCO选择的选择，其不利影响包括眼压升高，囊状物质水肿，角膜内皮细胞损伤，视网膜脱离和眼内透镜（IOL）斑点：评估Nd：yag激光胶囊术前后的角膜内皮结构和功能，PCO患者使用镜面显微镜。材料和方法：这是一个未来的观察在Bharati Vidyape（被视为大学）医学院和医院，Sangli，Maharashtra，印度的50名患者的50名患者的50名患者，在50名患者中进行的研究。本研究是在2020年10月20日至2月2021年间的四个月内进行的.Patiants在受影响的眼睛中进行ND：YAG激光纤维素术，并在一周内随访，一个月后的后期。分枝微分SCopy用于评估激光毛囊前后内皮细胞的内皮细胞密度（ECD），变异系数（CV）和六面性。用于社会科学的统计包装（SPSS）26.0版用于统计分析.Chisquare测试和ANOVA测试是在本研究中应用的重要性。结果：47例患者（94％）的BCVA≥6患者（94％），47例患者（94％）的≥6 / 18后一个月postprocedure.Mean ECD prelaser为2356.76细胞/ mm 2，这prelaser ECD并在一周后一个月之间在降低到2231.8细胞/ mm 2 1周和2199.2细胞/ mm 2在一个月时的后续理想管材差为124.96细胞/ mm 2和157.56细胞/ mm 2，分别，这是在一个月（p <0.0001）。该平均CV prelaser为33.74统计学显著，1周为35.58和在一个月时它是在CV 37.22.The差从Prelaser身份到一个月是统计签名IFICANT（P <0.0001）。基线的平均六六角形为65.34％，在一周内随访，60.42％下降至62.02％。一个月和基线之间的六六角形差异有统计学意义（P <0.0001）结论：Nd：YAG激光囊为PCO.However治疗的安全，有效和非侵入性的方法，它会导致结构和功能角膜内皮细胞的损伤。

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