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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Comparison of Manual, Semi-Automated and Fully-Automated Enzymatic Methods For High Density Lipoprotein (HDL) Estimation- A Cross-sectional Study
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Comparison of Manual, Semi-Automated and Fully-Automated Enzymatic Methods For High Density Lipoprotein (HDL) Estimation- A Cross-sectional Study

机译：用于高密度脂蛋白（HDL）估计的手动，半自动和全自动酶法的比较 - 横截面研究

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Spherical particles with nonpolar neutral lipids at the center and more polar amphipathic lipids at their surface are called Lipoproteins.HDL aids in cholesterol homeostasis by removing it from cells by several different mechanisms.The results of HDL Cholesterol (HDL-C) should be accurate and reliable, especially for the patients with borderline values, where the variation resulting from the methodology used may interfere with the interpretation of clinical scenario by the doctors.Aim: To compare the results of HDL values obtained by using three different technical methods.Materials and Methods: The present study was conducted using 30 serum samples from the Biochemistry laboratory of KLE Society’s Dr.Prabhakar Kore Charitable Hospital and Medical Research Centre, Belagavi, Karnataka, India for HDL values, each for the three different technical methods (fullyautomated, semi-automated and manual method).The data obtained was analysed statistically by computing descriptive statistics the mean, standard deviation and correlation coefficient.Results: Results of serum samples analysed for HDL-C values ranged from 31-79 mg/dl (mean 43.1) in fully-automated analyser, 28.06 to 75.18 (mean 39.6) in semi-automated and 27.06 to 62.7mg/dl (mean 39.7) using manual method.There was significant difference in the mean values of HDL-C values obtained using the three different methods and positive correlation was established on comparing semi-automated and manual method (Semi-automated v/s manual method, r=0.827) and found to be statistically significant.Conclusion: As HDL estimation is routinely done in many of the clinical laboratories, a sound knowledge of the HDL values obtained using different techniques can help the clinicians while ordering for the test and also for diagnosing & monitoring of the cases with various lipid abnormalities.
机译：在其中心的中心和更多的极性两亲性脂质的球形颗粒通过几种不同的机制从细胞中除去胆固醇稳态而被称为脂蛋白稳态的脂蛋白。结果是准确的和可靠，特别是对于具有边缘值的患者，其中由所用方法产生的变化可能会干扰医生的临床情景的解释：比较通过使用三种不同技术方法获得的HDL值的结果。材料和方法：目前的研究是使用来自Kle Society博士的生物化学实验室的30个血清样本进行了Prabhakar Kore慈善医院和医学研究中心，Belagavi，Karnataka，Karnataka，Karnataka，每个用于HDL值，每个都是三种不同的技术方法（全自动，半自动和手动方法）。通过计算描述性统计数据来统计分析所获得的数据平均值，标准偏差和相关系数。结果：用于HDL-C值分析的血清样品的结果范围为31-79mg / dL（平均43.1），在半自动和半自动和27.06至62.7mg / dl（平均39.7）使用手动方法。使用三种不同方法获得的HDL-C值的平均值差异是显着的，并在比较半自动和手动方法时建立正相关（半自动v / s手动方法，r = 0.827）并发现统计学意义。结论：随着HDL估计在许多临床实验室中经常完成，使用不同技术获得的HDL值的声音知识可以帮助临床医生在订购时有助于临床医生测试和诊断＆amp;监测各种脂质异常的病例。

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