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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Clinical Study on Outcome of Treatment for Herpes Zoster
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Clinical Study on Outcome of Treatment for Herpes Zoster

机译：疱疹疱疹治疗结果的临床研究

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Herpes Zoster (HZ) is caused by reactivation of Varicella Zoster Virus (VZV).It is characterised by occurrence of grouped vesicles on erythematous base which involves the entire dermatome innervated by a single spinal or cranial sensory ganglion and is associated with radicular pain.Antivirals (Acyclovir, Famciclovir and Valacyclovir) started within 72 hours of onset of lesions are the agents of choice.Aim: To study the clinical manifestations, co-morbidities, efficacy and safety of Acyclovir, complications and sequelae associated with HZ.Materials and Methods: A three year longitudinal cohort study was conducted in 212 adult patients (>18 years of age) suffering with HZ in the Department of Dermatology, Dhiraj General Hospital, Pipariya, Gujarat, India.In this study 212 patients with HZ were prescribed oral Acyclovir in a dose of 800 mg five times a day for seven days.All patients were analysed in terms of clinical manifestations, pre-existing co-morbidities and incidence of complications.The clinical history and findings were recorded in a prestructured proforma.All patients were subjected to cytological examination (Tzanck smear) and Human immunodeficiency viruses (HIV) testing Enzyme-Linked Immunosorbent Assay (ELISA).Diagnosis was made primarily on the basis of clinical findings and presence of multinucleated giant cells in Tzanck smear.All the patients were treated with Oral Acyclovir.Cases were followed-up fortnightly for six weeks and evaluated for relief of symptoms, treatment outcome and complications/sequelae.Results: Two hundred and twelve cases were studied, 142 cases were in the 4th and 5th decades of life, 63 cases had comorbidities like diabetes mellitus in 31, autoimmune diseases like pemphigus vulgaris, systemic lupus erythematosus, rheumatoid arthritis and inflammatory bowel disease in 19 and AIDS in eight cases.Five cases had malignancy/lymphomas and were receiving chemotherapy for the same.In the majority, HZ occurred de novo without any co-morbidities.The most common dermatomes involved were cervical and thoracic.Out of 212 cases, oral Acyclovir 800 mg was well tolerated by 74.Most common complication was Postherpetic Neuralgia (PHN), seen in 80 cases.Conclusion: The treatment of HZ with Oral Acyclovir 800 mg five times a day for seven days is efficacious for healing of skin lesions and also reduces the chances of PHN if instituted within 72 hours.
机译：疱疹疱疹（HZ）是由突变菌扎带病毒（VZV）的再活化引起的。旨在通过在红斑碱上发生分组的囊泡，其涉及由单个脊柱或颅骨感官神经节接头的整个皮肤物，并且与加静脉疼痛有关。antivirals （Acyclovir，Famciclovir和Valacyclovir）在病变的72小时内开始是选择的代理商。研究临床表现，患有与Hz.materials和方法相关的Acyclovir，并发症和后遗症的临床表现，持续的疗效和安全性：三年的纵向队列研究是在212名成年患者（> 18岁）中患有HZ，Dhiraj综合医院，古吉拉特，古吉拉特邦，古吉拉特邦，古吉拉特邦，古吉拉特邦，古吉拉特邦患者。本研究212例Hz患者被规定的口服acyclovir每天七次800毫克的剂量为七天。所有患者都在临床表现，预先存在的共同生命和顺应性的发病率方面进行了分析临床历史和发现被记录在一个不稳定的形式中。所有患者受到细胞学检查（Tzanck Smear）和人免疫缺陷病毒（HIV）测试酶联免疫吸附测定（ELISA）.Diagnosis主要是在基础上进行的临床发现与坦克涂片中多核巨细胞的存在。所有患者用口服Acyclovir.Case治疗，每两周一次，并评估症状，治疗结果和并发症/后遗症。结果：二百和十二研究了病例，142例患者在4岁和50年生命中，63例患有糖尿病等糖尿病，31例，自身免疫性疾病，如Pemphigus，Systemic Lupus红斑，199例，19例患有19例和艾滋病的8例。有恶性/淋巴瘤的五种病例和接受化疗同样。在大多数情况下，Hz发生了De Novo没有任何Co-Morb符号。所涉及的最常见的皮肤病是宫颈癌和胸椎。OUT 212例，口服ACYCLOVIR 800mg耐受良好74.多种共同的并发症是POSTHERPETIC患者（PHN），在80例中观察到。结论：HZ与口服的治疗Acyclovir 800毫克每天五次七天，对于皮肤病变的愈合有效，并且如果在72小时内进行制定，则降低了PHN的机会。

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