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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Phenotypic Variation of Insulin Resistance among Polycystic Ovarian Syndrome Patients in Semiurban North Indian Population
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Phenotypic Variation of Insulin Resistance among Polycystic Ovarian Syndrome Patients in Semiurban North Indian Population

机译：半城北印度人口多囊卵巢综合征患者胰岛素抗性的表型变异

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Polycystic Ovarian Syndrome (PCOS) is a common endocrine disorder in the women of reproductive age.Studies show that there is an intensive relationship between insulin and gonadal function.As per Rotterdam Criteria, there are four major phenotypes of PCOS with different presentation.Early detection of Insulin Resistance (IR) and consequential prevention of Metabolic Syndrome (MS) associated with PCOS may lead to better prospect for the disease.Aim: To find the pattern of IR in all the phenotypes of PCOS in relation to Waist Hip Ratio (WHR), Body Mass Index (BMI) and Testosterone and thereby, providing data for designing phenotype specific treatment of the disease.Materials and Methods: In this cross-sectional observational study, fasting insulin and fasting glucose were analysed to calculate HOMA-IR (Homeostasis Model Assessment) and Testosterone for total 144 female subjects of reproductive age group (18-40 years).Subjects were classified in to four groups as per Rotterdam Criteria.Complete PCOS (PCOCOM), PCO with Oligo/Anovulation (PCO-O), Anovulation with Hyperandrogenism (O-HA), and PCO with Hyperandrogenism (PCO-HA).Regression analysis was done to find the relation among the study variables.ANOVA was used to analyse the significant variance among the groups.Results: IR was found to be maximum among O-HA phenotype (2.4±0.37) and lowest among PCO-HA phenotypes (1.3±0.22).Regression analysis shows that there exist significant associations between IR and BMI (t=4.96, p=0.001) as well as between IR and WHR (t=2.97, p=0.003).No independent association between testosterone and IR was observed.Conclusion: Significant difference of IR, WHR, and BMI was observed among the four phenotypes of PCOS.Due to increased IR, O-HA and PCO-COM phenotypes are more predisposed to Cardiometabolic consequences of PCOS.
机译：多囊卵巢综合征（PCOS）是生殖时代妇女的常见内分泌疾病。研究所表明，胰岛素和性腺功能之间存在密集的关系。每个鹿特丹标准，PCOS的四个主要表型具有不同的介绍。评估胰岛素抵抗（IR）和后续预防与PCOS相关的代谢综合征（MS）可能导致疾病更好的前景。优势：在PCO的所有表型中找到与腰臀比（WHR）的所有表型模式，体重指数（BMI）和睾酮，从而提供用于设计对疾病表型特异性治疗的数据。在这种横截面观察研究中，分析禁食胰岛素和空腹葡萄糖计算HOMA-IR（稳态模型评估）和睾酮总共144例生殖年龄组（18-40岁）。根据鹿特丹标准分类为四组.CO MPLETE PCOS（PCOCOM），PCO与寡核酸/无糖（PCO-O），具有高衰变（O-HA）的滑动和具有高衰老性的PCO（PCO-HA）。进行了分析，以找到研究变形的关系.ANOVA用于分析群体之间的显着方差。结果：IR在O-HA表型（2.4±0.37）中最大，在PCO-HA表型中最低（1.3±0.22）。配额分析表明存在重要的协会IR和BMI（T = 4.96，P = 0.001）以及IR和WHR（T = 2.97，P = 0.003）。没有观察到睾酮和IR之间的独立关联。结论：IR，WHR和在PCOS.due的四种表型中观察到BMI，以增加IR，O-HA和PCO-COM表型更为倾向于PCOS的心脏异常后果。

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