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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Clinicopathological Features, Management and Outcome of Paediatric Solid Renal Tumours in Southeast Nigeria: The Need for Protocol and Multidisciplinary Collaboration
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Clinicopathological Features, Management and Outcome of Paediatric Solid Renal Tumours in Southeast Nigeria: The Need for Protocol and Multidisciplinary Collaboration

机译：尼日利亚东南部儿科固体肾脏肿瘤的临床病理特征，管理和结果：议定书和多学科合作

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Renal malignancies are common in children and they constitute 6-7% of all childhood tumours and nephroblastoma is the most common solid renal tumour in children.Currently, standardised institutional protocols in management of renal tumours in children are the norm.Large scale collaborative studies have started emerging, yet not much has been documented on the clinical presentation, pathology and outcome of solid renal tumours particularly in Africa.Aim: To review the presentations, pathology and the management-outcome of solid renal tumour in the centre in the absence of a coordinated protocol and multi disciplinary collaboration.Materials and Methods: This was a nine and a half year longitudinal retrospective audit study of consecutive patients with solid renal tumours managed in a single tertiary centre: Nnamdi Azikiwe University Teaching Hospital, Nnewi, Southeast Nigeria.It took place from January 2009-June 2018.Relevant data on demography, clinical features, management and outcome were extracted from records.Results were analysed using Statistical Package for Social Sciences (SPSS) version 22.Categorical data were tested for independence using Chi-square test and significant p-value set at <0.05.Results: Twenty two paediatric cases (15 males and 7 females) were included in the study.The mean age at presentation was 50.10±45.18 months.The mean duration of symptoms was 5.5 months; 21 (95.5%) presented with abdominal masses while 6 (27.3%) had gross haematuria and 13 (59.1%) were emaciated.Tumours involved left kidney in 15 (68%).Histological reports were available in 9 cases with nephroblastoma being the most common 6 (27.3%).The most common stage was stage 3, 10 (45.5%) and most common procedure was nephroureterectomy, 11 (50%).Neo-adjuvant and adjuvant therapies were inconsistent.Conclusion: Late presentation, discordant treatment protocol, non completion of treatment and poor collaboration, were found to contribute largely to poor outcome of solid renal tumours in children in our setting.It is strongly believed that adoption of standard protocol and a multidisciplinary collaboration in management will improve records keeping and outcome.
机译：肾脏恶性肿瘤是常见于儿童，他们占所有儿童肿瘤的6-7％，并肾母细胞瘤是最常见的实体肿瘤的肾在children.Currently，标准化机构协议小儿肾肿瘤的管理是norm.Large规模合作研究有开始出现的，但没有多少已被记录在临床表现，病理和固体肾肿瘤的成果特别是在Africa.Aim：要查看演示文稿，病理学和实体肿瘤的肾在中心在没有管理的成果协调协议和多学科collaboration.Materials和方法：这是连续病人在一个单一的三级医疗中心管理的固体肾肿瘤九一年半纵向追溯审计研究：阿布贾大学教学医院，内维，东南亚Nigeria.It了地方从人口2009年1月，月2018.Relevant数据，临床特征，管理和成果使用统计软件包社会科学（SPSS）版本22.Categorical数据使用卡方检验和显著p值设定在<0.05。结果独立测试从records.Results提取进行了分析：二十二个儿科病例（男性15例和7名女）被列入在介绍study.The平均年龄为50.10±45.18个月，症状的平均时间为5.5个月; 21（95.5％）呈现腹部肿块，而6（27.3％）有肉眼血尿和13（59.1％）是emaciated.Tumours参与左肾15例（68％）。组织学报告9例可与肾母细胞瘤是最。常见6（27.3％）的最常见的阶段是阶段3，10（45.5％）和最常见的程序性肾，11（50％）新辅助和辅助治疗都是inconsistent.Conclusion：晚期介绍，不和谐的治疗方案，处理和协作较差的未完成性，被发现在我们的setting.It强烈认为，采用标准协议和管理多学科协作将提高记录保持和结果在很大程度上有助于实体肾肿瘤的预后不良的儿童。

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