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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Alteration in Steroid Hormone and HER2/ neu Receptor Status Following Neoadjuvant Chemotherapy in Triple Negative Breast Cancer. Is There Any Hope?
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Alteration in Steroid Hormone and HER2/ neu Receptor Status Following Neoadjuvant Chemotherapy in Triple Negative Breast Cancer. Is There Any Hope?

机译：在三重阴性乳腺癌中的Neoadjuvant化疗之后，对类固醇激素和HER2 / Neu受体状态的改变。 有希望吗？

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Breast cancer continues to be the most common cancers among women in India.The Triple Negative Breast Cancer (TNBC) is a heterogeneous group of malignancy which is often aggressive and has a worse prognosis.Aim: The aim of this study was to assess the hormone receptor and HER2/neu status with platinum based chemotherapy in TNBC.Materials and Methods: The study was analysed retrospectively in a tertiary care centre of West Bengal from Januay 2017 to December 2019.Forty TNBC patients of Locally Advanced Breast Cancer (LABC) cases who received carboplatin along with neoadjuvant chemotherapy (study group) were compared with other group of 64 TNBC patients (control group) who did not receive any chemotherapy making a total of 104 cases of TNBC patients who were selected for the study.All the patients in both the groups had modified radical mastectomy.The study group of 40 TNBC patients who received chemotherapy also showed pathological partial response.Masterchart was prepared comprising patient’s age, menopausal status, family history, therapy history, histo-morphological features, hormone receptor and HER2/ neu status after platinum added chemotherapy.Oestrogen Receptor (ER)/Progesterone Receptor (PR) were considered positive, if >1% tumour cell nuclei were immunoreactive and negative, if it was otherwise.HER-2/neu score of 3+ was taken as positive by Immunohistochemistry (IHC) method.Statistical analysis for descriptive purposes, percentages and mean were calculated.Comparison of both the groups was done by Pearson’s Chi-squared and Fisher’s-exact test.Significance level was considered at p-value <0.05) and ER status (p<0.05) while change in PR status was found to be statistically insignificant.Conclusion: The study showed significant alteration in hormonal and HER2/neu receptor status in TNBC patients receiving platinum added neoadjuvant chemotherapy.This study found statistical significance and justifies re-evaluation of these Hormone Receptor (HR) and HER2/neu markers in residual tumour after chemotherapy.
机译：乳腺癌仍然是印度女性中最常见的癌症。三重阴性乳腺癌（TNBC）是一种异质的恶性肿瘤，往往是侵略性的，并且预测较差：本研究的目的是评估激素TNBC中基于铂化疗的受体和HER2 / Neu现状。关于2019年12月至2019年12月的西孟加拉邦三级护理中心分析了该研究.Horty TNBC患者局部晚期乳腺癌（Labc）患者与Neoadjuvant化疗（研究组）一起接受的Carboplatin与其他64名TNBC患者（对照组）进行比较，他们没有收到任何化疗，该组在任何化疗中都有104例选择用于研究的TNBC患者。所有患者都在两者患者中该群体已经修饰了自由基乳房切除术。40名接受化疗的TNBC患者的研究组也显示出病理部分反应。准备包含PA的Asterchart Tient的年龄，更年期状态，家族史，治疗史，组织形态特征，激素受体和HER2 / Neu状态在铂添加后添加到阅览室阅读软体症（ER）/孕酮受体（PR）中被认为是阳性的，如果> 1％肿瘤细胞，则认为阳性受体（ER）/孕酮受体（PR）核是免疫反应性和阴性的，如果它是否则的，则用免疫组织化学（IHC）方法被视为阳性的-2 / Neu得分。用于描述性目的的统计分析，计算百分比和平均值。完成两组的比例。由Pearson的Chi Squared和Fisher-ExpligeS测试。在P值<0.05）和ER状态（P <0.05）时考虑了义率水平，同时发现PR状态的变化是统计上微不足道的。结论：该研究显示出显着的改变在接受铂的TNBC患者中荷尔蒙和HER2 / Neu受体状态增加Neoadjuvant化疗。本研究发现统计学意义并证明了对这些激素受体（HR）和HER2 / Neu Mark的再评估化疗后残留肿瘤。

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