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首页> 外文期刊>Canadian journal of animal science >Effects of the lipid-coated zinc oxide dietary supplement on intestinal mucosal morphology and gene expression associated with the gut health in weanling pigs challenged with enterotoxigenic Escherichia coli K88
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Effects of the lipid-coated zinc oxide dietary supplement on intestinal mucosal morphology and gene expression associated with the gut health in weanling pigs challenged with enterotoxigenic Escherichia coli K88

机译：肠岭猪肠道脊髓肠粘膜形态和基因表达对肠岭猪的肠粘膜形态和基因表达的影响肠鼠肠毒性大肠杆菌K88

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Effects of a lipid-coated zinc oxide (ZnO) Shield Zn ? (SZ) vs. ZnO were evaluated. Forty 25-d-old weanling pigs were fed a nursery diet supplemented with 100?mg kg ?1 Zn with ZnO (ZnO-100), ZnO-2500, SZ-100, -200, or -400. All piglets were challenged orally with 5?×?10 8 colony-forming units of enterotoxigenic Escherichia coli K88 on day 7 and euthanized on day 14. The fecal consistency score (FCS) was less for the SZ group vs. ZnO-100 ( P ??0.05). The intestinal villus height:crypt depth ratio and goblet cell density were greater for the SZ group vs. ZnO-100. By regression analyses, SZ-100 to -200 and SZ-300 to -400 were comparable to ZnO-2500 in the FCS and intestinal variables, respectively. The jejunal mucosal mRNA level did not differ between the SZ group and either ZnO group in insulin-like growth factor-I and multiple structural proteins and cytokines including zonula occludens protein (ZO) 1 and interleukin (IL) 10 except for lower ZO-1 and IL-10 mRNA levels for the SZ group than for ZnO-2500 and ZnO-100, respectively. The ZO-1 mRNA level regressed positively on the supplemental SZ concentration. Results suggest that SZ play a role in epithelial barrier function and inflammation by modulating the expression of ZO-1 and IL-10.
机译：脂质涂覆的氧化锌（ZnO）屏蔽Zn的效果？ （SZ）对ZnO进行了评估。 45 d-D古老的断奶猪喂养养苗膳食，该幼儿园饮食补充有100μmgkgα1zn，ZnO（ZnO-100），ZnO-2500，SZ-100，-200或-400。所有仔猪在第7天使用5？×10 8个形成肠毒素大肠杆菌K88并在第14天安乐死。Sz组对ZnO-100的粪便一致性评分（FCS）较低（P ？＆ 0.05）。肠绒毛高度：Crypt深度比和脚螺纤维细胞密度对于SZ组与ZnO-100更大。通过回归分析，SZ-100至-200和SZ-300至-400分别与FCS和肠变量中的ZnO-2500相当。胰岛素样生长因子-i和多种结构蛋白质和细胞因子的Sz组和ZnO组之间的Jejunal粘膜mRNA水平没有区别在内，除了下ZO-1之外，包括Zonula obcludens蛋白（Zo）1和白细胞介素（IL）10之间的细胞因子SZ组的IL-10 mRNA水平分别比ZnO-2500和ZnO-100分别为ZnO-2500和ZnO-100。 ZO-1 mRNA水平对补充SZ浓度肯定地回归。结果表明，SZ通过调节ZO-1和IL-10的表达，SZ在上皮屏障功能和炎症中发挥作用。

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