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首页> 外文期刊>Chemical Science International Journal >Characterization of the Molecular Lipophilicity of Mycolactones A/B and C, Infectious Factors of Mycobacterium ulcerans Agent of Buruli Ulcer
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Characterization of the Molecular Lipophilicity of Mycolactones A/B and C, Infectious Factors of Mycobacterium ulcerans Agent of Buruli Ulcer

机译：蒙斯酮A / B和C的分子亲脂性分子脂肪菌的分子亲脂性因子的特征，乌拉氏溃疡溃疡药物的传染性因素

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The work was undertaken as part of the Buruli ulcer control program. It is particularly about the determination of the lipophilicity of mycolactones A/B and C, infectious factors of Mycobacterium ulcerans , the agent of Buruli ulcer. The REKKER method and some free software such as MOLINSPIRATION, ACD/ChemSketch and EPIWED were used for the determination of the lipophilicity of mycolactones A/B and C. Very high logP values were found and respectively ranged from 12.11 to 11.41 for mycolactone A/B and 11.69 to 11.58 for mycolactone C. These values obtained from this coefficient, show that mycolactones A/B and C are naturally lipophilic and that actually reflects their effective presence in the subcutaneous fat of the infected area. These results are very encouraging and promising. They are key factors for a better understanding of the biological activities of the two mycolactones and pave the way for the proposal of a mechanism to annihilate their destructive effects.
机译：这项工作是作为布鲁利溃疡控制计划的一部分进行的。 特别是测定mycolactones a / b和c的亲脂性，传染性溃疡的传染性因素，乌拉氏溃疡的药剂。 REKKER方法和一些自由软件如莫斯泊素，ACD / Chemsketch和epiwed用于测定Mycolactones A / B和C的亲脂性。发现非常高的LOMP值，分别为mycolictone A / B的12.11至11.41 对于MycolicTone C.11.69至11.58。从该系数获得的这些值表明，Mycolactones A / B和C是天然亲脂性的，其实际上反映了它们在受感染区域的皮下脂肪中的有效存在。 这些结果非常令人鼓舞和有前途。 它们是更好地理解两种Mycolictones的生物学活性的关键因素，并为机制提出危及其破坏性效果的建议铺平了道路。

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