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New Biological Targets in Fungi and Novel Molecule under Development: A Review

机译：在开发中的真菌和新型分子新的生物学靶点：综述

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Antifungal therapeutics is confronted today with the challenge of drug resistance of most fungal germs to current antifungal drugs. Faced with this situation, the search for new and more efficient antifungal molecules that avoid the phenomenon of drug resistance becomes an urgent task. The design of new antifungal drugs acting on new biological targets and/or by innovative mechanisms of action is essential in the fight against fungal infections. Current advances in molecular biology have identified new targets for the development of new antifungal therapy. Several biological targets for the development of new antifungal agents are currently being explored. Amongst these, the most promising are BET (Bromodomain and Extra-Terminal) proteins, Homoserine transacetylase (HTA), mannan cell wall, Glycosylphosphatidylinositols (GPI) anchor biosynthesis, Histone deacetylases, Sphingolipid biosynthesis, D9 fatty acid desaturase and Chitin biosynthesis. This review summarizes the new biological targets and their inhibitors under development as potential new antifungal drugs.
机译：抗真菌治疗剂今日面临着最低质量真菌毒细胞对目前的抗真菌药物的挑战。面对这种情况，寻找新的和更有效的抗真菌分子，避免耐药现象成为紧急任务。新的抗真菌药物的设计，作用于新的生物学目标和/或通过创新的行动机制对抗真菌感染是必不可少的。分子生物学的当前进步已经确定了新的抗真菌疗法的开发的新目标。目前正在探索用于开发新的抗真菌剂的几种生物学目标。其中，最有前途的是下注（溴琼酱和末端）蛋白质，均静脉晶状体酶（HTA），甘露酮晶体，甘露糖基磷脂酰肌醇（GPI）锚生物合成，组蛋白脱乙酰酶，鞘脂生物合成，D9脂肪酸去饱和酶和甲壳素生物合成。本综述总结了新的生物靶标及其抑制剂作为潜在的新抗真菌药物。

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