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首页> 外文期刊>Egyptian Journal of Medical Human Genetics >Expression of miR-146a and miR-155 in Egyptian patients with Behet's disease: clinical significance and relationship with disease activity
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Expression of miR-146a and miR-155 in Egyptian patients with Behet's disease: clinical significance and relationship with disease activity

机译：MIR-146A和MIR-155在埃及患者塞（Beget）疾病患者的表达：临床意义与疾病活动关系

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Background:Beh?et’s disease (BD) is a systemic vasculitis disorder with multifactorial immunopathogenesis and associated with significant morbidity and mortality. MicroRNAs (miRNAs) are involved in the pathogenesis of inflammatory diseases. MiR-146 and miR-155 are known key regulators of immune response. This study was conducted to determine the expression of miRNA-146a and miRNA-155 in patients with BD and to link their possible association with the clinical manifestations and activity of this disease to evaluate their role as diagnostic or prognostic markers. A total of 60 patients with BD and 25 age- and gender-matched healthy controls were examined in a case-control study from October 2017 to September 2018 for the expression levels of miR-146a and miR-155 using singleplexTaqMan two-step stem loop quantitative reverse transcription real-time polymerase chain reaction (qRT-PCR).ResultsPatients with BD had significantly lower miR-146a levels than control subjects (P < 0.001). Regarding the miR-155 expression level, no statistically significant differences were detected between patients and healthy controls (P = 0.736). The expression level of miR-146a showed no significant association with the different clinical manifestations of patients with BD.ConclusionThis study suggests the possibility that miR-146a expression in patients with BD is involved in the pathogenesis of disease. Furthermore, it can be used as a diagnostic biomarker and a therapeutic target for BD in the future.
机译：背景：Beh？等疾病（BD）是一种具有多重致病性免疫病变的全身血管障碍，与显着的发病率和死亡率相关。 MicroRNA（miRNA）参与炎症性疾病的发病机制。 MIR-146和MIR-155是已知的免疫应答的关键调节因子。本研究进行了测定了BD患者MiRNA-146a和miRNA-155的表达，并将其可能与本病的临床表现和活性联系起来，以评估它们作为诊断或预后标志物的作用。在2017年10月至2018年9月，在2018年10月至2018年9月，在2018年10月至2018年9月的表达水平使用Singleplextaqman双步杆环定量逆转录实时聚合酶链反应（QRT-PCR）。具有BD的MiR-146A水平明显低于对照对象（ P <0.001）。关于miR-155表达水平，患者和健康对照之间没有检测到统计学上显着的差异（ p = 0.736）。 miR-146a的表达水平显示出与bd的患者的不同临床表现没有显着关联。结论该研究表明，BD患者MiR-146a表达的可能性涉及疾病的发病机制。此外，它可以用作未来BD的诊断生物标志物和治疗目标。

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