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Insights from a qualitative analysis of a gene expression model with delays ? ?

机译:具有延迟的基因表达模型的定性分析的见解 < CE:Cross-Ref Refid =“Fn1”>

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Delays appear in the dynamics of many systems due to non-vanishing reaction times of control systems. In biochemical systems, long sequences of repeated steps, especially in biopolymerization processes, can be modeled by delays. However, modelling systems with delays is often complicated by physical constraints, such as the requirement that solutions representing concentrations of chemical species remain positive. In this work, we consider a model for a detoxifying enzyme whose synthesis is controlled by its substrate. The model includes binding-site clearance delays, caused by the time required for an RNA polymerase or ribosome to clear its binding site before another such machine can bind. The existence of a positive equilibrium and the positivity and boundedness of solutions of the corresponding delay-differential equations are proven. In addition, the stability of the model is studied using the “small-gain” theorem.
机译:由于控制系统的非消失反应时间,延迟出现在许多系统的动态中。 在生化系统中,可以通过延迟模拟生物化学系统,特别是在生物聚合过程中的重复步骤的长序列。 然而,具有延迟的建模系统通常因物理限制而变得复杂,例如要求代表化学物质浓度的解决方案保持阳性。 在这项工作中,我们考虑一种用于解毒酶的模型,其合成由其基材控制。 该模型包括结合位点的间隙延迟,由RNA聚合酶或核糖体清除其在另一种这种机器可以结合之前清除其结合位点所需的时间引起的。 证明了相应的延迟微分方程溶液的正平平衡和阳性和界限的存在。 此外,使用“小增益”定理研究了模型的稳定性。

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