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首页> 外文期刊>The biochemical journal >Protein tyrosine phosphatases in cell adhesion
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Protein tyrosine phosphatases in cell adhesion

机译：细胞粘附中的蛋白质酪氨酸磷酸酶

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Adhesive structures between cells and with the surrounding matrix are essential for the development of multicellular organisms. In addition to providing mechanical integrity, they are key signalling centres providing feedback on the extracellular environment to the cell interior, and vice versa. During development, mitosis and repair, cell adhesions must undergo extensive remodelling. Post-translational modifications of proteins within these complexes serve as switches for activity. Tyrosine phosphorylation is an important modification in cell adhesion that is dynamically regulated by the protein tyrosine phosphatases (PTPs) and protein tyrosine kinases. Several PTPs are implicated in the assembly and maintenance of cell adhesions, however, their signalling functions remain poorly defined. The PTPs can act by directly dephosphorylating adhesive complex components or function as scaffolds. In this review, we will focus on human PTPs and discuss their individual roles in major adhesion complexes, as well as Hippo signalling. We have collated PTP interactome and cell adhesome datasets, which reveal extensive connections between PTPs and cell adhesions that are relatively unexplored. Finally, we reflect on the dysregulation of PTPs and cell adhesions in disease.
机译：细胞与周围基质之间的粘合结构对于多细胞生物的发展至关重要。除了提供机械完整性之外，它们还是向细胞内部提供有关细胞内环境的关键信号中心，反之亦然。在开发，有丝分裂和修复期间，细胞粘连必须经历广泛的重塑。这些配合物中蛋白质的后翻版修饰用作活性的开关。酪氨酸磷酸化是细胞粘附性的重要修饰，其由蛋白质酪氨酸磷酸酶（PTP）和蛋白酪氨酸激酶动态调节。在组装和维护细胞粘连中，几个PTP涉及，然而，它们的信令功能仍然定义不足。 PTP可以通过直接去磷酸化粘合剂复合物组分或用作支架起作用。在这篇综述中，我们将专注于人类PTP，并讨论其在主要附着力复合物中的个体作用，以及河马信号传导。我们已经整理了PTP互乱组和细胞纸质数据集，该数据集揭示了比较探测的PTP和细胞粘连之间的广泛连接。最后，我们反思了疾病中PTP和细胞粘连的失调。

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