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首页> 外文期刊>BMC Rheumatology >The development of rapidly progressive glomerulonephritis associated with both antineutrophil cytoplasmic antibody-associated vasculitis and anti-glomerular basement membrane nephritis in the course of nontuberculous mycobacterium infection: a case report
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The development of rapidly progressive glomerulonephritis associated with both antineutrophil cytoplasmic antibody-associated vasculitis and anti-glomerular basement membrane nephritis in the course of nontuberculous mycobacterium infection: a case report

机译：在非泛骨分枝杆菌感染过程中，伴有抗嗜酸性细胞质抗体相关血管炎和抗肾小球基底膜肾炎的快速进展性肾小球肾炎的发展：案例报告

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Antineutrophil cytoplasmic antibodies (ANCA) and Anti-glomerular basement membrane (GBM) antibodies often induce rapidly progressive glomerulonephritis (RPGN). Some reports have demonstrated RPGN with the sequential appearance of ANCA then anti-GBM antibodies, suggesting that ANCA may induce the development of anti-GBM antibodies. Whereas, many reports have shown that the development of ANCA is associated with various infectious diseases, such as non-tuberculous mycobacterial infection. A 65-year-old woman with pulmonary non-tuberculous mycobacterial (NTM) infection was monitored without treatment. One year later, serum myeloperoxidase (MPO)- ANCA were elevated (14.1?U/mL (normal value ?3.0?U/ml)). A high fever and RPGN appeared 1?year later, and serum MPO-ANCAs were 94.1?U/mL. Anti-GBM antibodies were also detected. A renal biopsy revealed crescentic glomerulonephritis with linear deposits of IgG and C3c along the GBM and interstitial inflammation with endarteritis of arterioles. The diagnosis was RPGN associated with anti-GBM nephritis and ANCA-associated vasculitis. This report shows that preceding NTM infection may have induced ANCA and anti-GBM antibodies and caused the development of RPGN.
机译：抗替托利罗氏菌细胞质抗体（ANCA）和抗肾小球基底膜（GBM）抗体通常诱导迅速逐渐培养的肾小球肾炎（RPGN）。有些报道已经证明RPGN具有ANCA的连续外观，然后是抗GBM抗体，表明ANCA可以诱导抗GBM抗体的发育。然而，许多报道表明，ANCA的发展与各种传染病有关，例如非结核性分枝杆菌感染。监测一名65岁的女性肺非结核分枝杆菌（NTM）感染没有治疗。一年后，血清髓过氧化物酶（MPO） - ANCA升高（14.1？U / mL（正常值＆ 3.0？U / ml））。高烧和RPGN出现了1？一年后，血清MPO-ANCAS是94.1 u / ml。还检测到抗GBM抗体。肾活检揭示了Crentic肾小球肾炎，沿着GBM和Chertitiens炎症性炎症术，C3C的线性沉积和动脉炎。诊断是与抗GBM肾炎和ANCA相关血管炎相关的RPGN。本报告显示，在NTM感染之前可能诱导ANCA和抗GBM抗体并导致RPGN的发育。

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