Impact of anti-glomerular basement membrane antibodies and glomerular neutrophil activation on glomerulonephritis in experimental myeloperoxidase-antineutrophil cytoplasmic antibody vasculitis

Kanzaki Go; Nagasaka Shinya; Higo Seiichiro; Kajimoto Yusuke; Kanemitsu Takafumi; Aoki Michiko; Nagahama Kiyotaka; Natori Yasuhiro; Tsuboi Nobuo; Yokoo Takashi; Shimizu Akira

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Impact of anti-glomerular basement membrane antibodies and glomerular neutrophil activation on glomerulonephritis in experimental myeloperoxidase-antineutrophil cytoplasmic antibody vasculitis

机译：抗肾小球基底膜抗体和肾小球中性粒细胞活化对实验性髓过氧化物酶-抗中性粒细胞胞浆抗体血管炎中肾小球肾炎的影响

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Antineutrophil cytoplasmic antibody (ANCA) and neutrophil interactions play important roles in ANCA-associated vasculitis (AAV) pathogenesis. However, mechanisms underlying the pathogenesis of crescent formation in ANCA-associated vasculitis have not been completely elucidated. To ascertain the involvement of these interactions in necrotizing crescentic glomerulonephritis (NCGN), we used an AAV rat model and investigated the effects of the anti-myeloperoxidase (MPO) antibody (Ab) titer, tumor necrosis factor alpha (TNF-alpha), granulocyte colony-stimulating factor (G-CSF) and subnephritogenic anti-glomerular basement membrane (GBM) Abs, as proinflammatory stimuli.

机译：抗中性粒细胞胞浆抗体（ANCA）和中性粒细胞相互作用在ANCA相关血管炎（AAV）发病机理中起重要作用。然而，尚未完全阐明在与ANCA相关的血管炎中新月形成的发病机理的机制。为了确定这些相互作用参与坏死性新月形肾小球肾炎（NCGN），我们使用了AAV大鼠模型并研究了抗髓过氧化物酶（MPO）抗体（Ab）滴度，肿瘤坏死因子α（TNF-alpha），粒细胞的作用集落刺激因子（G-CSF）和亚肾炎性抗肾小球基底膜（GBM）Abs作为促炎性刺激。

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《Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association》 |2016年第4期|共12页
作者
Kanzaki Go; Nagasaka Shinya; Higo Seiichiro; Kajimoto Yusuke; Kanemitsu Takafumi; Aoki Michiko; Nagahama Kiyotaka; Natori Yasuhiro; Tsuboi Nobuo; Yokoo Takashi; Shimizu Akira;
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正文语种 eng
中图分类器官移植术;
关键词
ANCA; chemokine; chemokine receptor; necrotizing crescentic glomerulonephritis; neutrophil;

机译：ANCA;趋化因子;趋化因子受体;坏死性新月形肾小球肾炎;中性粒细胞;

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1. Impact of anti-glomerular basement membrane antibodies and glomerular neutrophil activation on glomerulonephritis in experimental myeloperoxidase-antineutrophil cytoplasmic antibody vasculitis [J] . Kanzaki Go, Nagasaka Shinya, Higo Seiichiro, Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association . 2016,第4期

机译：抗肾小球基底膜抗体和肾小球中性粒细胞活化对实验性髓过氧化物酶-抗中性粒细胞胞浆抗体血管炎中肾小球肾炎的影响
2. Thrombotic thrombocytopenic purpura in a patient with rapidly progressive glomerulonephritis with both anti-glomerular basement membrane antibodies and myeloperoxidase anti-neutrophil cytoplasmic antibodies [J] . Hitoshi Watanabe, Wataru Kitagawa, Keisuke Suzuki, Journal of contemporary psychotherapy . 2011,第1期

机译：患者血栓形成血小板细胞紫癜患者患者迅速逐渐肾小球肾炎，抗肾小球基底膜抗体和髓氧基酶抗中性粒细胞细胞质抗体
3. Thrombotic thrombocytopenic purpura in a patient with rapidly progressive glomerulonephritis with both anti-glomerular basement membrane antibodies and myeloperoxidase anti-neutrophil cytoplasmic antibodies. [J] . Watanabe H, Kitagawa W, Suzuki K, Clinical and experimental nephrology . 2010,第6期

机译：快速抗肾小球肾炎合并抗肾小球基底膜抗体和髓过氧化物酶抗中性粒细胞胞浆抗体的患者的血栓性血小板减少性紫癜。
4. Trace of Antibody to Myeloperoxidase with Nanocrystal Quantum Dot-Labeled Antibody Recognizing Activating Neutrophils [C] . Akiyoshi Hoshino, Tomokazu Nagao, Kenji Yamamoto, Colloidal Quantum Dots for Biomedical Applications; Progress in Biomedical Optics and Imaging; vol.7 no.19 . 2006

机译：纳米晶量子点标签抗体识别活化中性粒细胞的痕迹髓过氧化物酶抗体。
5. Anti-glomerular basement membrane glomerulonephritis: Characterization of an epitope, antibody response, and the potential role of IL-4Ralpha in disease progression. [D] . Robertson, Julie Milayna. 2009

机译：抗肾小球基底膜肾小球肾炎：抗原表位的表征，抗体反应以及IL-4Ralpha在疾病进展中的潜在作用。
6. Combined membranous nephropathy and crescentic glomerulonephritis with concurrent anti-glomerular basement membrane antibody and myeloperoxidase-specific anti-neutrophil cytoplasmic antibody [O] . Yoichi Iwafuchi, Takashi Morita, Yuko Oyama, 2013

机译：合并膜性肾病和新月型肾小球肾炎并发抗肾小球基底膜抗体和髓过氧化物酶特异性抗中性粒细胞胞浆抗体
7. Impact of anti-glomerular basement membrane antibodies and glomerular neutrophil activation on glomerulonephritis in experimental myeloperoxidase-antineutrophil cytoplasmic antibody vasculitis [O] . Go Kanzaki, Shinya Nagasaka, Seiichiro Higo, 2015

机译：抗肾小球基底膜抗体和肾小球中性粒细胞激活对实验性髓氧基酶 - 抗癫痫酶细胞质抗体血管炎的肾小球肾细胞炎

Impact of anti-glomerular basement membrane antibodies and glomerular neutrophil activation on glomerulonephritis in experimental myeloperoxidase-antineutrophil cytoplasmic antibody vasculitis

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