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首页> 外文期刊>Clinical and Translational Medicine >Inflammation‐induced macrophage lysyl oxidase in adipose stiffening and dysfunction in obesity
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Inflammation‐induced macrophage lysyl oxidase in adipose stiffening and dysfunction in obesity

机译：炎症诱导的巨噬细胞溶血基氧化酶在肥胖加强和肥胖中的功能障碍中

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Obesity is associated with adipose tissue (AT) fibrosis with aggregation or crosslinking of collagen fibers. 1,2 Lysyl oxi- dase(LOX). 3,4 Our data showed higher second harmonic generation sig- nals as well as collagen crosslinks in ob/ob AT than wild- type(WT)AT(Figure1AandB).Inob/obAT,expressionof LOX was highly upregulated among the LOX family, while a similar trend of LOX increment was also found in high- fat diet-induced obese mice (Figure 1C and S1). The ob/ob activity (Figure 1D and E). Increased AT stiffness was pre- viously found in obese subjects non-invasively. 5 Our direct measurements by atomic force microscopy (AFM) showed a similar trend by yielding higher effective Young’s mod- ulus (E eff ) in ob/ob mice and obese human subcutaneous AT (Figure 1F and G). With adipose tissue derived from obese subjects before and after weight loss surgery, we observed significantly attenuated LOX expression but not that of other LOX family members (Figure 1H), accom- panied by reduced stiffness (Figure 1I). While obesity- induced physical property changes in AT may confine adipocytefunctions, 6 tural changes in AT as well as the augmented LOX during obesity await investigation.
机译：肥胖与脂肪组织（AT）纤维化与胶原纤维的聚集或交联有关。 1,2溶酶氧化物（LOX）。 3,4我们的数据显示出更高的谐波产生信号以及在野生型（WT）的OB / OB中的胶原交联（图1AandB）.inob / Obat，LOX的表达在LOX家族中高度上调，而且在高脂饮食诱导的肥胖小鼠中也发现了LOX增量的类似趋势（图1C和S1）。 OB / OB活动（图1D和E）。在肥胖的受试者中，在肥胖的僵硬地发现僵硬的僵硬的增加。 5原子力显微镜（AFM）的直接测量通过在OB / OB小鼠和肥胖人皮下（图1F和G）中产生更高的杨氏的Mod- ulus（E off）来显示出类似的趋势。通过脂肪脱离手术前后衍生自肥胖受试者的脂肪组织，我们观察到显着减弱的LOX表达，而不是其他LOX家族成员（图1H）的，通过减少刚度（图1i）。虽然肥胖症诱导的物理性质在可能限制脂肪减压，但在肥胖期间，在肥胖期间的增强LOX的特性变化以及增强的LOX。

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