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首页> 外文期刊>Advances in Rheumatology >Nephrolithiasis in gout: prevalence and characteristics of Brazilian patients
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Nephrolithiasis in gout: prevalence and characteristics of Brazilian patients

机译：痛风中的肾脏病：巴西患者的患病率和特点

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The aims of this article were to assess the prevalence of nephrolithiasis and the factors associated with nephrolithiasis in Brazilian patients with primary gout. One hundred twenty-three patients with primary gout were recruited from a tertiary referral hospital in S?o Paulo, Brazil. All patients underwent ultrasonography and had their clinical and laboratory characteristics assessed. One hundred fifteen (93.5%) patients were male, with a mean age of 62.9?±?9.4?years. Twenty-three (18.7%) patients had asymptomatic nephrolithiasis (detected only by ultrasonography), 7 (6.0%) had symptomatic nephrolithiasis (detected by ultrasonography and a positive clinical history), and 13 (10.0%) had a history of kidney stones, but ultrasonography at evaluation did not show nephrolithiasis. Therefore, 35.0% of the patients had nephrolithiasis (detected either by ultrasonography and/or a positive clinical history). Nephrolithiasis was associated with male gender (43 [100%] vs 72 [90%], p?=?0.049), the use of potassium citrate (13 [30.2%] vs 0, p???0.001) and the use of medications for diabetes (10 [23.3%] vs 8 [10%], p?=?0.047) and dyslipidemia (15 [34.9%] vs 10 [12.5%], p?=?0.003); benzbromarone had an inverse association with nephrolithiasis (21 [48.8%] vs 55 [68.8%], p?=?0.030). In patients with and without nephrolithiasis, no differences were found in the laboratory and ultrasonography characteristics, including serum uric acid levels, urinary uric acid excretion and urine pH. The prevalence of nephrolithiasis in primary gout was 35.0%, and 18.7% of the patients were asymptomatic. Nephrolithiasis was associated with male gender, diabetes and dyslipidemia. A positive history of nephrolithiasis probably biased the prescription of potassium citrate and benzbromarone.
机译：本文的目的是评估肾血红素病的患病率和巴西初级痛风患者的肾病患者相关的因素。从巴西的第三次推荐医院招募了一百二十三名初级痛风患者。所有患者都经过超声检查，并进行了临床和实验室特征。一百十五（93.5％）患者是男性，平均年龄为62.9？±9.4？年。二十三（18.7％）患者具有无症状的肾血红病（仅通过超声检测），7（6.0％）有症状肾病（通过超声检查检测和阳性临床史），13（10.0％）有肾结石的历史，但是在评估中的超声检查没有显示出肾血症。因此，35.0％的患者患有肾血红病（通过超声检查和/或阳性临床病史检测）。肾状二病原与男性性别有关（43 [100％] Vs 72 [90％]，p？= 0.049），使用柠檬酸钾（13 [30.2％] Vs 0，p≤0.001）和使用药物用于糖尿病（10 [23.3％] Vs 8 [10％]，P？= 0.047）和血脂血症（15 [34.9％] Vs 10 [12.5％]，p？= 0.003）; Benzbromarone与肾血红素的反比异性相结合（21 [48.8％] Vs 55 [68.8％]，p？= 0.030）。在患有肾血清腺症和没有肾的患者中，在实验室和超声检查中没有发现差异，包括血清尿酸水平，尿酸尿酸排泄和尿液pH。原发性痛风中肾的患病率为35.0％，18.7％的患者无症状。肾血症与男性性别，糖尿病和血脂血症有关。肾血红素的阳性历史可能偏向柠檬酸钾和苯溴甲酮的处方。

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