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首页> 外文期刊>International Journal of Electrochemical Science >Electrochemical Sensors for Berberine Hydrochloride Determination in Commercial Products and Bio-Fluids
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Electrochemical Sensors for Berberine Hydrochloride Determination in Commercial Products and Bio-Fluids

机译：商业产品和生物液中盐酸小檗碱测定的电化学传感器

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摘要

The present study describes the development of three electrochemical sensors conducted by the interaction of berberine hydrochloride (BRB) with phosphotungestic acid (plastic membrane), sodium tetraphenyl borate (coated wire), and ammonium reineckate (coated graphite) sensors. Under optimum experimental conditions the effect of membrane content, type of solvent mediator, soaking time, hydrogen ion concentration of the test solutions and the estimation of the analyte in the presence of foreign species were studied. The data confirmed that the developed sensors gave potential responses of 54.10 ± 0.5, 57.00 ± 0.5 and 59.00 ± 0.5 mV decade-1 at ambient temperature for (berberine– phosphotungstate, BRB-PT), (berberine–tetraphenylborate, BRB-TPB) and (berberine–reineckate, BRB-AR) sensors, respectively, over drug concentration ranges of 1.0×10-7 - 1.0×10-3 , 1.0×10-8 - 1.0×10-2 and 1.0×10-7 - 1.0×10-2 mol L-1 with lower detection limits 5.0×10-8 , 5.0×10-9 and 5.0×10-8 mol L-1 for the above suggested sensors, respectively. The suggested sensors provide high selectivity, precise and sensitivity for the determination of BRB within the average pH range 3-9. Validity of the method was performed for the suggested electrochemical probe following ICH guidelines. The suggested sensors were favorably exploited for the estimation of BRB in commercial products and biofluids.
机译：本研究描述了三种电化学传感器的开发，通过盐酸小檗碱（BRB）与磷酸磷酸（塑料膜），四苯基硼酸钠（涂布丝）和铵重建（涂层石墨）传感器进行三种电化学传感器。研究了在最佳实验条件下，研究了膜含量，溶剂介质类型，浸泡时间，试验溶液的氢离子浓度以及在外来物种存在下估计分析物的效果。该数据证实，在环境温度（Berberine-Phosphotentate，BRB-PT），（Berberine-tetraphenylborate，Brb-TPB）和（分别在药物浓度范围内，比Berberine-Reinckate，BRB-AR）传感器1.0×10-7 - 1.0×10-3，1.0×10-8 - 1.0×10-2和1.0×10-7 - 1.0×对于上述建议的传感器，10-2摩尔L-1具有较低检测限值5.0×10-8,5.0×10-9和5.0×10-8 mol L-1。建议的传感器提供高选择性，精确和灵敏度，用于测定平均pH范围3-9内的BRB。对ICH指南的建议的电化学探针进行了方法的有效性。建议的传感器有利地利用商业产品和生物流体中的BRB估算。

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