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首页> 外文期刊>RSC Advances >An electrochemical sensor based on poly(procaterol hydrochloride)/carboxyl multi-walled carbon nanotube for the determination of bromhexine hydrochloride
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An electrochemical sensor based on poly(procaterol hydrochloride)/carboxyl multi-walled carbon nanotube for the determination of bromhexine hydrochloride

机译：基于聚（Procaterol盐酸盐）/羧基多壁碳纳米管的电化学传感器，用于测定盐酸溴己酮的测定

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摘要

Poly(procaterol hydrochloride) (p-ProH) polymeric film was successfully deposited onto the carboxyl multi-walled carbon nanotube (CMWCNT) modified glass carbon electrode (GCE) to construct a p-ProH/CMWCNT composite modified GCE. Due to the synergistic effect of p-ProH and CMWCNT in the composite, the developed sensor can enormously enhance the oxidation peak current of bromhexine hydrochloride (BrH) at ca. + 0.90 V. Based on this appearance, an electrochemical method was established for the sensitive and selective determination of BrH with differential pulse voltammetry (DPV). Various conditions affecting the peak current response of BrH were studied and optimized. Under the best conditions, the oxidation peak current of BrH is linear to its concentration in two linear dynamic ranges of 0.2-1.0 mol L-1 (R = 0.9948) and 1.0-8.0 mol L-1 (R = 0.9956), with a detection limit of 0.1 mol L-1 (S/N = 3). Interference experiment indicated that the as-prepared electrochemical sensor showed wonderful selectivity to the recognition of BrH and was free from disturbance of many other electro-active substances such as dopamine, ascorbic and uric acid. Finally, the practicability of the BrH sensor was verified by the satisfactory results acquired from the BrH determination in pharmaceutical preparation and human serum.
机译：将聚（盐酸盐酸盐）（P-ProH）聚合物膜成功沉积在羧基多壁碳纳米管（CMWCNT）改性玻璃碳电极（GCE）上以构建P-ProH / CMWCNT复合改性GCE。由于P-PROH和CMWCNT在复合材料中的协同效应，发达的传感器可以极大地增强CA的盐酸溴己酮（BRH）的氧化峰值电流。 + 0.90 V.基于这种外观，建立了一种电化学方法，用于用差分脉冲伏安法（DPV）对BRH的敏感和选择性测定。研究了影响BRH的峰值电流响应的各种条件，并进行了优化。在最佳条件下，BRH的氧化峰值电流在0.2-1.0mol L-1（R = 0.9948）和1.0-8.0mol L-1（R = 0.9956）的两个线性动态范围内是线性的。检出限为0.1mol L-1（S / N = 3）。干扰实验表明，制备的电化学传感器对BRH的识别表现出精彩的选择性，并且没有许多其他电活性物质如多巴胺，抗坏血和尿酸的干扰。最后，通过来自药物制剂和人血清的BRH测定获得的令人满意的结果验证了BRH传感器的实用性。

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  • 来源
    《RSC Advances》 |2019年第21期|共11页
  • 作者

    Kong Dexian; Han Libin; Wang Zeming; Jiang Lili; Zhang Qian; Wu Qiong; Su Jinwei; Lu Chunhua; Chen Guonan;

  • 作者单位

    Fujian Agr &

    Forestry Univ Coll Life Sci Fuzhou 350002 Fujian Peoples R China;

    Fujian Agr &

    Forestry Univ Coll Life Sci Fuzhou 350002 Fujian Peoples R China;

    Fujian Agr &

    Forestry Univ Coll Life Sci Fuzhou 350002 Fujian Peoples R China;

    Fuzhou Univ Coll Chem Fuzhou 350108 Fujian Peoples R China;

    Fujian Agr &

    Forestry Univ Coll Life Sci Fuzhou 350002 Fujian Peoples R China;

    Fujian Agr &

    Forestry Univ Coll Life Sci Fuzhou 350002 Fujian Peoples R China;

    Fujian Agr &

    Forestry Univ Coll Life Sci Fuzhou 350002 Fujian Peoples R China;

    Fuzhou Univ Coll Chem Fuzhou 350108 Fujian Peoples R China;

    Fuzhou Univ Coll Chem Fuzhou 350108 Fujian Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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