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Childhood Immunization and COVID-19: An Early Narrative Review

机译：儿童免疫和Covid-19：早期叙述审查

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The COVID-19 pandemic has evolved into arguably the largest global public health crisis in recent history—especially in the absence of a safe and effective vaccine or an effective anti-viral treatment. As reported, the virus seems to less commonly infect children and causing less severe symptoms among infected children. This narrative review provides an inclusive view of scientific hypotheses, logical derivation, and early analyses that substantiate or refute such conjectures. At the completion of a relatively less restrictive search of this evolving topic, 13 articles—all published in 2020, were included in this early narrative review. Directional themes arising from the identified literature imply the potential relationship between childhood vaccination and COVID-19—either based on the potential genomic and immunological protective effects of heterologous immunity, or based on observational associations of cross-immunity among vaccines and other prior endemic diseases. Our review suggests that immune response to the SARS-CoV-2 virus in children is different than in adults, resulting in differences in the levels of severity of symptoms and outcomes of the disease in different age groups. Further clinical investigations are warranted of at least three childhood vaccines: BCG, MMR, and HEP-A for their potential protective role against the SARS-CoV-2 virus.
机译：Covid-19大流行在近期历史中可以说是最大的全球公共卫生危机 - 特别是在没有安全有效的疫苗或有效的抗病毒治疗。如报道称，病毒似乎较少地感染儿童并导致感染儿童的严重症状。该叙述审查提供了科学假设，逻辑推导，以及早期分析的包容性观点，即证明或反驳这种猜想。在完成这种不太限制的情况下，在这一演变的主题中搜索，13篇 - 全部在2020年出版，纳入了这一早期叙事审查。由鉴定的文献产生的定向主题暗示儿童疫苗接种和Covid-19之间的潜在关系 - 基于异源免疫的潜在基因组和免疫保护作用，或者基于疫苗和其他先前流动性疾病之间的交叉影响的观察联想。我们的评论表明，儿童SARS-COV-2病毒的免疫应对与成人不同，导致不同年龄组疾病症状和结果的严重程度的差异。进一步的临床调查是有至少三种儿童疫苗的临床调查：BCG，MMR和HEP-A，用于对SARS-COV-2病毒的潜在保护作用。

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