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Analysis of PFAS Levels and Associations with Adolescent Anthropometric Outcomes in NHANES

机译：与奈瑟斯青少年人体计量结果的PFAS水平与关联分析

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Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are found in some consumer products due to their heat resistance and durability. However, there is potential for these substances to bioaccumulate in humans. It is relevant to investigate biological effects of these chemicals, as studies have suggested early life exposure may impact human developmental outcomes such as infant birth weight and youth adiposity. The objective of the current study was to determine if a relationship exists between increasing levels of certain PFAS and anthropometrics in adolescents ages 12 - 18. The three PFAS examined were: perfluorodecanoic acid (PFDeA), 2-(N-methyl-perfluoroctane sulfonamido) acetic acid (Me-PFOSA-AcOH), and perfluoroundecanoic acid (PFUA). The data was obtained from the National Health and Nutrition Examination Survey (NHANES) from the years 2011-2012 ( N = 287) and 2013-2014 ( N = 344). An additional analysis combined data from 3 NHANES survey cycles using sampling weights for the years 2011-2016 ( N = 875) to generate a larger sample size of detectable PFAS. PFAS concentrations were classified as above or below the lower limit of detection (LLOD) to evaluate differences in weight, waist circumference, BMI (body mass index), and height using Student’s t-tests. These same anthropometric outcomes were examined as continuous variables in linear regression models and were stratified by sex. In the 2013-2014 dataset, there were significant inverse associations between female concentrations of PFUA and PFDeA with waist circumference (PFUA β = − 0.056; 95% CI, − 0.106, − 0.005; PFDeA β = − 0.06; 95% CI, − 0.10, − 0.02), weight-for-age z-score (PFUA β = − 0.40; 95% CI, − 0.74, − 0.05; PFDeA β = − 0.38; 95% CI, − 0.64, − 0.12), and BMI-for-age z-score (PFUA β = − 0.48; 95% CI, − 0.86, − 0.10; PFDeA β = − 0.45; 95% CI, − 0.73, − 0.16). In the 2011-2012 dataset, males displayed a significant inverse relationship between PFDeA and waist circumference ( β = − 0.08; 95% CI, − 0.14, − 0.02), weight-for-age z-score ( β = − 0.49; 95% CI, − 0.88, − 0.11), and BMI-for-age z-score ( β = − 0.44; 95% CI, − 0.84, − 0.05). In the combined analysis of NHANES years 2011-2016, there were significant inverse associations with PFUA and PFDeA and weight-for-age z-score, waist circumference, and BMI-for-age z-score. In the given sample years, there was no compelling evidence for a relationship between any of the perfluoroalkyl chemicals and height, nor between Me-PFOSA-AcOH and any of the body measures after adjusting for age, sex, and race/ethnicity. This suggests that PFUA and PFDeA exposure in adolescents may be related to smaller waist circumference, weight, and BMI, but longitudinal studies are recommended to confirm these findings.
机译：由于其耐热性和耐用性，在一些消费产品中发现了全氟烷基和聚氟烷基物质（PFAs）。然而，这些物质存在对人类的生物累积。鉴于调查这些化学品的生物学效果，因为研究表明早期寿命可能会影响人类发育成果，如婴儿出生体重和青年肥胖。目前研究的目的是确定是否存在在12-18岁的青少年某些PFAS和蒽米的水平之间存在关系。检查的三种PFAS是：全氟二癸酸（PFDEA），2-（N-甲基 - 全氟辛烷磺胺酰胺）乙酸（ME-PFOSA-ACOH）和全氟癸酸（PFUA）。从2011 - 2012年（N = 287）和2013-2014年（n = 344）的国家卫生和营养考试调查（NHANES）获得了数据。额外的分析组合数据来自3个NHANES调查周期的数据，使用2011-2016年的采样权重（n = 875），以产生可检测PFA的更大样本大小。将PFAS浓度分类为上述或低于检测（LLOD）的下限，以评估重量，腰围，BMI（体重指数）和使用学生的T检验的差异。将这些相同的人体测量结果被检查为线性回归模型中的连续变量，并被性别分层。在2013-2014数据集中，PFUA和腰围的PFDEA的女性浓度之间存在显着的逆关联（PFUAβ=＆amp; 0.056; 95％CI，＆amp; 0.106，＆amp; 0.005 ; PFDEAβ=＆amp;＃8722; 0.06; 95％CI，＆amp;＃8722; 0.10，＆amp; 0.02），重量Z-score（pfuaβ=＆amp;＃8722; 0.40; 95 ％ci，＆amp;＃8722; 0.74，＆amp; 0.05; pfdeaβ=＆amp;＃8722; 0.38; 95％ci，＆amp;＃8722; 0.64，＆amp; 0.12）和bmi-for - Z分数（PFUAβ=＆amp;＃8722; 0.48; 95％CI，＆amp; 0.86，＆amp; 0.10; pfdeaβ=＆amp;＃8722; 0.45; 95％CI，＆amp; ＃8722; 0.73，＆amp;＃8722; 0.16）。在2011-2012数据集中，雄性在PFDEA和腰围（β=＆amp;＃8722; 0.08; 95％CI，＆amp; 0.14，＆amp; 0.02），重量 - z得分（β=＆amp;＃8722; 0.49; 95％CI，＆amp;＃8722; 0.88，＆amp; 0.11）和BMI-for-age Z-score（β=＆amp;＃8722 ; 0.44; 95％CI，＆amp;＃8722; 0.84，＆amp; 0.05）。在2011-2016的NHANES年份的综合分析中，与PFUA和PFDEA的显着反相副作用和急剧Z评分，腰围和BMI-EVES Z分数。在给定的样本年份中，任何全氟烷基化学物质和高度之间的关系都没有令人信服的证据，在调整年龄，性别和种族/种族后，Me-Pfosa-acoh和Me-Pfosa-acoh和任何身体措施之间的关系。这表明青少年的PFUA和PFDEA暴露可能与较小的腰围，重量和BMI有关，但建议纵向研究确认这些发现。

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