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首页> 外文期刊>The Egyptian Journal of Neurology, Psychiatry and Neurosurgery >Early disability in ambulatory patients with multiple sclerosis: optical coherence tomography versus visual evoked potentials, a comparative study
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Early disability in ambulatory patients with multiple sclerosis: optical coherence tomography versus visual evoked potentials, a comparative study

机译：多发性硬化症患者的早期残疾：光学相干断层扫描与视觉诱发潜力，一个比较研究

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Multiple sclerosis (MS) is a common cause of neurological disabilities in adults and commonly affects the visual pathway. The objective of this study is to assess and compare the sensitivity of visual evoked potentials (VEP) and optical coherence tomography (OCT) as measures of early disability in ambulatory patients with MS. Forty-four patients with MS with Expanded Disability Status Scale (EDSS) of ≤ 4.5 (ambulatory patients) and 14 healthy controls participated in this study. Patients were classified into 3 groups according to EDSS. Patients with EDSS of 0–1.5 formed the “No disability,” patients with EDSS of 2–3 formed the “Minimal to mild disability,” and finally patients with EDSS of 3.5–4.5 formed the “Moderate to significant disability” groups. N75/P100 amplitude, P100 latency, retinal nerve fiber layer (RNFL) thickness, and ganglion cell layer complex (GCLC) thickness were measured. Patients showed significantly lower N75/P100 amplitude, higher P100 latency, lower RNFL, and GCLC thicknesses compared to controls. However, there were non-significant changes in P100 latency, N75/P100 amplitude, and GCLC thickness among the 3 groups for both patients with and without history of optic neuritis (ON). On contrary, RNFL thickness was significantly different between the three groups for both patients with and without history of ON. Factorial ANOVA revealed non-significant disability × History of ON interaction. Compared to VEP parameters, RNFL thickness was a sensitive correlate with the various degrees of early disability in fully ambulatory patients with MS whatever the history of ON.
机译：多发性硬化症（MS）是成人神经疾病的常见原因，并且通常影响视觉途径。本研究的目的是评估和比较视觉诱发电位（VEP）和光学相干断层扫描（OCT）作为MS的动态患者早期残疾措施的敏感性。四十四名患有≤4.5（动态患者）和14例健康对照的患者患有扩大的残疾状态规模（EDS）。患者根据EDS分为3组。 EDSS为0-1.5的患者形成了“无残疾”2-3的EDS患者形成了“最小的残疾，”，最后患者的EDSS为3.5-4.5，形成“中度至重大残疾”组。测量N75 / P100振幅，P100等待时间，视网膜神经纤维层（RNFL）厚度和神经节细胞层复合物（GCLC）厚度。与对照相比，患者显示出显着降低的N75 / P100振幅，更高的P100潜伏，下RNFL和GCLC厚度。然而，对于两组患者，P100潜伏期，N75 / P100幅度和GCLC厚度的非显着变化，对于视神经炎（ON）的历史，3组。相反，两组患者的rnfl厚度显着差异，患者毫无历史。因子Anova揭示了非重大残疾×互动的历史。与VEP参数相比，RNFL厚度与在历史悠久的历史上的全动态患者中的各种早期残疾中的敏感性。

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