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首页> 外文期刊>Journal of International Medical Research >Glutathione S-transferase Omega 2 DD genotype is associated with an increased risk of sporadic amyotrophic lateral sclerosis in Chinese men
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Glutathione S-transferase Omega 2 DD genotype is associated with an increased risk of sporadic amyotrophic lateral sclerosis in Chinese men

机译：谷胱甘肽S-转移酶OMEGA 2 DD基因型与中国男性散发性肌萎缩侧硬化的风险增加有关

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Objective To investigate whether GSTA1 , GSTO2 , and GSTZ1 are relevant to an increased risk of amyotrophic lateral sclerosis (ALS) in a Chinese population. Methods In this study, 143 sporadic ALS (sALS) patients (83 men, 60 women) and 210 age- and sex-matched healthy subjects were enrolled. Blood samples were collected by venipuncture. Genomic DNA was isolated by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) according to the manufacturer’s instructions. The potential associations between ALS and GSTA1 , GSTO2 , and GSTZ1 polymorphisms were estimated using chi-squared analysis and unconditional logistic regression. Results The D allele and genotype frequencies of GSTO2 were increased in sALS patients compared with healthy subjects, indicating that the GSTO2 DD genotype was associated with an increased risk of sALS (odds ratio [OR]?=?3.294, 95% confidence interval [CI]?=?1.039–10.448). However, a significant association between the DD genotype and the risk of sALS was evident in men only (OR?=?7.167, 95% CI?=?1.381–37.202). Conclusion This study revealed that the D allele and genotype frequencies of GSTO2 were increased in sALS patients. The GSTO2 DD genotype was associated with an increased risk of sALS in men in a Chinese population.
机译：目的探讨GSTA1，GSTO2和GSTZ1是否与中国人口中的肌营养侧面硬化（ALS）的风险增加相关。本研究中的方法，143名孢子（SAL）患者（83名男性，60名女性）和210名年龄和性别匹配的健康受试者。静脉穿刺收集血样。根据制造商的说明，通过聚合酶链反应限制片段长度多态性（PCR-RFLP）分离基因组DNA。使用Chi平方分析和无条件逻辑回归估计ALS和GSTA1，GSTO2和GSTZ1多态性之间的潜在关联。结果与健康受试者相比，SALS患者中GSTO2的D等位基因和基因型频率增加，表明GSTO2 DD基因型与含量的风险增加有关（差距[或] = 3.294,95％置信区间[CI [CI ]？=？1.039-10.448）。然而，DD基因型之间的重要关联仅在男性中明显明显（或？=？7.167,95％CI？=？1.381-37.202）。结论本研究表明，SALS患者中GSTO2的D等位基因和基因型频率增加。 GSTO2 DD基因型与中国人口中男性含量的风险增加有关。

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