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首页> 外文期刊>Journal of International Medical Research >Global prevalence of long-term neurodevelopmental impairment following extremely preterm birth: a systematic literature review
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Global prevalence of long-term neurodevelopmental impairment following extremely preterm birth: a systematic literature review

机译：在极度早产之后的全球长期神经发育障碍的患病率：系统文献综述

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Objective Neurodevelopmental impairment (NDI) is a major complication of extreme prematurity. This systematic review was conducted to summarize the worldwide long-term prevalence of NDI associated with extreme prematurity. Methods Embase and MEDLINE databases were searched for epidemiologic and observational/real-world studies, published in English between 2011 and 2016, reporting long-term prevalence of NDI (occurring from 1 year) among extremely preterm infants born at gestational age (GA) ≤28 weeks. Results Of 2406 articles identified through searches, 69 met the protocol NDI definition (24 North America, 25 Europe, 20 Rest of World). Prevalence of any severity NDI in North America was 8%–59% at 18 months to 2 years, and 11%–37% at 2–5 years; prevalence of moderate NDI in Europe was 10%–13% at 18 months to 2 years, 3% at 2–5 years, and 9%–19% at ≥5 years; prevalence of any NDI in Rest of World was 15%–61% at 18 months to 2 years, and 42% at 2–5 years (no North America/Rest of World studies reported any NDI at ≥5 years). A trend toward higher prevalence of NDI with lower GA at birth was observed. Conclusions Extreme prematurity has a significant long-term worldwide impact on neurodevelopmental outcomes.
机译：目标神经发育障碍（NDI）是极度早产的主要复杂性。进行了这种系统审查，总结了与极端早产的NDI的长期普遍存在。方法在2011年和2016年期间，在英语发表的流行病学和观测/现实研究中搜索了embase和Medline数据库，报告了在孕龄（GA）≤的极端早产儿28周。结果通过搜查确定了2406篇文章，69符合“北美，25个欧洲，世界其余20宗议定书”议定书。北美的任何严重性NDI的患病率为18个月至2年的8％-59％，同比为2 - 5年的11％-37％;欧洲中度NDI的患病率为18个月至2岁的10％-13％，3％在2-5岁，≥5年达到9％-19％;世界其他地区的任何NDI的患病率为18个月至2年的15％-61％，2-5岁的42％（世界上没有北美/世界学习的其余部分报告≥5年的任何NDI）。观察到出生时下GA较低的NDI患病率较高的趋势。结论极端早产是对神经发育成果的显着长期全球影响。

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