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首页> 外文期刊>Journal of International Medical Research >Relationship between AGT rs2493132 polymorphism and the risk of coronary artery disease in patients with NAFLD in the Chinese Han population
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Relationship between AGT rs2493132 polymorphism and the risk of coronary artery disease in patients with NAFLD in the Chinese Han population

机译：<斜视切换=“是”> AGT RS2493132多态性和冠状动脉疾病中汉族人群患者冠状动脉疾病的风险

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Objective To investigate the relationship between angiotensin ( AGT ) rs2493132 gene polymorphism and the risk of developing non-alcoholic fatty liver disease (NAFLD) and coronary artery disease (CAD) in the Chinese Han population. Methods Polymerase chain reaction was performed to determine AGT genotypes. Anthropometric and clinical data were investigated and statistically analyzed in the clinical laboratory department of Qingdao Municipal Hospital. Results The AGT rs2493132 CT?+?TT genotype was an important risk factor for CAD in patients with NAFLD and NAFLD?+?CAD in healthy controls. The AGT rs2493132 T allele increased the risk of NAFLD?+?CAD in healthy controls. The AGT rs2493132 CT?+?TT genotype and T allele also significantly increased the risk of CAD in patients with NAFLD after adjustments for age, sex, and body mass index. In addition, AGT rs2493132 T allele carriers showed higher total cholesterol (TC) and low-density lipoprotein (LDL) levels compared with non-carriers. Conclusions The AGT rs2493132 CT?+?TT genotype and T allele significantly increased the risk of developing CAD in patients with NAFLD in the Chinese Han population. The AGT rs2493132 T allele was associated with increased serum TC and LDL levels.
机译：目的探讨血管紧张素（AGT）RS2493132基因多态性的关系，以及中国汉族人群中冠心病（CAD）发育非酒精性脂肪肝病（NAFLD）和冠状动脉疾病的风险。方法进行聚合酶链反应，以确定AGT基因型。在青岛市医院的临床实验室进行研究和统计学分析了人类学和临床数据。结果AGT RS2493132 CT？+ TT基因型是NAFLD和NAFLD患者CAD的重要危险因素？+？CAD在健康的控制中。 AGT RS2493132 T等位基因增加了NAFLD的风险？+？CAD在健康的控制中。 AGT RS2493132 CT？+ TT基因型和T等位基因还显着增加了NAFLD患者在调整年龄，性别和体重指数后患者CAD的风险。此外，与非载体相比，AGT RS2493132 T等位基因载体显示出更高的总胆固醇（TC）和低密度脂蛋白（LDL）水平。结论AGT RS2493132 CT？+ TT基因型和T等位基因显着提高了中国汉族人群中NAFLD患者开发CAD的风险。 AGT RS2493132 T等位基因与血清TC和LDL水平增加有关。

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