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首页> 外文期刊>BMC Medical Genomics >IL-17A polymorphism (rs2275913) and levels are associated with preeclampsia pathogenesis in Chinese patients
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IL-17A polymorphism (rs2275913) and levels are associated with preeclampsia pathogenesis in Chinese patients

机译：IL-17A多态性（RS2275913）和水平与中国患者的先兆子痫发病机制有关

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Preeclampsia (PE) is a pregnancy-related condition that affects both the infant and the mother. Although the role of various inflammatory molecules in PE has been demonstrated, the importance of pro-inflammatory molecules such as IL-17A, IL-23 is not well understood. In the present investigation, a potential association of common genetic variants in the IL-17A and IL-23A genes with PE was investigated. 115 PE clinically diagnosed patients who registered to the International Peace Maternity and Child Health Hospital were enrolled in this research. One hundred two pregnant women and 147 healthy Chinese women were also included. ELISA was used to measure IL-17A and IL-23 serum levels in all enrolled subjects. Common genetic polymorphisms in IL-17A (rs 2,275,913, rs1974226, and rs1974226), IL-23A (rs11171806), and IL-12B (rs3212227) were genotyped using the PCR-RFLP or TaqMan probe-based method. Elevated serum IL-17A levels were found in PE patients compared to pregnant (P??0.0001) and healthy women (P??0.0001). However, IL-23 levels were comparable across various clinical groups. In addition, heterozygous (GA) and minor allele (A) for IL-17A (rs2275913) and IL-23A (rs11171806) were more prevalent in PE patients compared to pregnant women indicating an important role in the predisposition to PE growth. Interestingly, IL-17A (r 2,275,913) mutants were associated with elevated IL-17A levels relative to wild type (GG). IL-17A (rs2275913) variants are associated with higher serum levels of cytokine, and predisposed PE development.
机译：Preclampsia（PE）是一种与妊娠相关的条件，影响婴儿和母亲。虽然已经证明了各种炎症分子在PE中的作用，但促炎分子如IL-17a，IL-23的重要性并不了解。在本研究中，研究了IL-17A和IL-23A基因中的常见遗传变体的潜在关联。 115 PE临床诊断患者登记在国际和平及儿童保健医院的患者均注册了这项研究。还包括一百两名孕妇和147名健康的中国女性。 ELISA用于测量所有注册受试者的IL-17A和IL-23血清水平。使用PCR-RFLP或Taqman探针的方法基因分型IL-17A（RS 2,275,913，RS11171806），IL-23a（RS11171806）和IL-12B（RS3212227）的常见遗传多态性。在PE患者中发现升高的血清IL-17a水平与孕孕（p≤≤01.0001）和健康女性（p？＆ 0.0001）。然而，IL-23水平在各种临床组中可比较。此外，与孕妇相比，IL-17A（RS2275913）和IL-23A（RS11171806）的杂合（GA）和次要等位基因（A）在PE患者中更为普遍，表明在PE生长的易感性中具有重要作用。有趣的是，IL-17A（R 2,275,913）突变体与相对于野生型（GG）的升高的IL-17A水平相关。 IL-17A（RS2275913）变体与更高的细胞因子水平和预处理的体育培养有关。

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