• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>BMC Medical Genomics >Identification of S1PR3 gene signature involved in survival of sepsis patients
【24h】

Identification of S1PR3 gene signature involved in survival of sepsis patients

机译：鉴定败血症患者存活的S1PR3基因签名

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Sepsis is a life-threatening complication of infection that rapidly triggers tissue damage in multiple organ systems and leads to multi-organ deterioration. Up to date, prognostic biomarkers still have limitations in predicting the survival of patients with sepsis. We need to discover more prognostic biomarkers to improve the sensitivity and specificity of the prognosis of sepsis patients. Sphingosine-1-phosphate (S1P) receptor 3 (S1PR3), as one of the S1P receptors, is a prospective prognostic biomarker regulating sepsis-relevant events, including compromised vascular integrity, antigen presentation, and cytokine secretion. Until now, no S1PR3-related prognostic gene signatures for sepsis patients have been found. This study intends to obtain an S1PR3-associated gene signature from whole blood samples to be utilized as a probable prognostic tool for patients with sepsis. We obtained an 18-gene S1PR3-related molecular signature (S3MS) from the intersection of S1PR3-associated genes and survival-associated genes. Numerous important immunity pathways that regulate the progression of sepsis are enriched among our 18 genes. Significantly, S3MS functions greatly in both the discovery and validation cohort. Furthermore, we demonstrated that S3MS obtains significantly better classification performance than random 18-gene signatures. Our results confirm the key role of S1PR3-associated genes in the development of sepsis, which will be a potential prognostic biomarker for patients with sepsis. Our results also focus on the classification performance of our S3MS as biomarkers for sepsis, which could also provide an early warning system for patients with sepsis.
机译：败血症是一种危及生命的感染并发症，可迅速触发多器官系统中的组织损伤，并导致多器官劣化。最新的，预后生物标志物仍然有局限性预测败血症患者的存活。我们需要发现更多预后的生物标志物，以提高败血症患者预后的敏感性和特异性。鞘氨氨酸-1-磷酸（S1P）受体3（S1PR3）作为S1P受体之一，是调节败血症相关事件的前瞻性预后生物标志物，包括受损的血管完整性，抗原呈递和细胞因子分泌。到目前为止，未发现败血症患者的S1PR3相关的预后基因签发。该研究旨在从全血样获得S1PR3相关基因签名，以用于败血症患者的可能预后工具。我们从S1PR3相关基因和生存相关基因的交叉点获得了18-基因的S1PR3相关分子签名（S3MS）。调节败血症进展的许多重要免疫途径在我们的18个基因中富集。显着地，S3MS在发现和验证队列中有很大的作用。此外，我们证明S3MS比随机18-基因签名获得明显更好的分类性能。我们的结果证实了S1PR3相关基因在败血症发展中的关键作用，这将是脓毒症患者的潜在预后生物标志物。我们的结果还专注于S3MS的分类性能作为败血症的生物标志物，也可以为败血症患者提供预警系统。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号