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首页> 外文学位 >Identification of distinct gene expression signatures in histologically normal epithelium from patients with different breast cancer risk.
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Identification of distinct gene expression signatures in histologically normal epithelium from patients with different breast cancer risk.

机译：在具有不同乳腺癌风险的患者中，从组织学上正常的上皮中鉴定出独特的基因表达特征。

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摘要

Genomic alterations exist before histological evidence of malignancy, yet cancer precursors are seriously understudied. Investigating these precursors would help elucidate the features of breast cancer initiation and progression. We hypothesized that the gene expression in histologically normal epithelium from breast cancer patients (HN) would differ from gene expression in histologically normal epithelium from reduction mammoplasty controls (RM). We found the gene expression profiles were different in the two tissues genes downregulated in HN include MAPK pathway components as well as transcription factors ( ATF3, ETS2, MAFF, and TXNIP).There are no studies of comprehensive gene expression in prophylactic mastectomy samples, although their clinical characteristics are well-studied. Knowledge of gene expression changes in these tissues could be integrated into existing risk-assessment models, improving their accuracy. We hypothesized gene expression in histologically normal epithelium of women at high breast cancer risk, undergoing prophylactic mastectomy (PM), would show greater similarity to HN samples than RM samples. We found the PM expression profile is more similar to HN samples than RM samples, with the exception of the genes in the MAPK pathway, which had a more similar expression signature to RMs than HNs.Breast cancer is a heterogeneous disease whose origin is unclear. Many studies have sought to define the transcriptome of tumors and classify them based on their gene expression. To date, few studies have focused on gene expression profiles in the histologically normal epithelium from women with breast cancer. Studying the earliest divergent features in ER+ and ER- breast cancer patients will help to develop more tailored therapies for specific types of the disease. We hypothesized there are differences in gene expression between histologically normal epithelium from ER+ and ER- breast cancer patients. We found that pathways implicated in ER+ carcinogenesis (the ESR and GATA3 Pathways) were present in histologically normal epithelium from ER+ patients, while immune response genes composed 32% of genes with a higher expression in histologically normal epithelium from ER- patients.The gene expression differences identified between the samples demonstrate identification of distinct early changes in breast carcinogenesis in specific patient populations. Identification of these early changes will help to accurately determine risk and develop more specific agents for breast cancer treatment and prevention.
机译：基因组改变在恶性肿瘤的组织学证据之前就已经存在，但对癌症前体的研究却严重不足。研究这些前体将有助于阐明乳腺癌的发生和发展特征。我们假设乳腺癌患者（HN）的组织学正常上皮中的基因表达与减少乳房成形术对照（RM）的组织学正常上皮中的基因表达不同。我们发现在HN中被下调的两个组织中的基因表达谱是不同的，包括MAPK通路成分以及转录因子（ATF3，ETS2，MAFF和TXNIP）。尽管没有进行预防性乳房切除术样品中全面基因表达的研究，但尚无研究他们的临床特征得到了充分研究。这些组织中基因表达变化的知识可以整合到现有的风险评估模型中，从而提高其准确性。我们假设接受预防性乳房切除术（PM）的高乳腺癌风险女性的组织学正常上皮中的基因表达与RM样本相比，与HN样本的相似性更高。我们发现PM的表达谱与HN的样品比RM的样品更相似，除了MAPK途径中的基因与RM的表达签名比HNs更相似。乳腺癌是一种异质性疾病，其起源尚不清楚。许多研究试图定义肿瘤的转录组，并根据其基因表达对其进行分类。迄今为止，很少有研究集中于乳腺癌女性的组织学正常上皮中的基因表达谱。研究ER +和ER-乳腺癌患者的最早分歧特征将有助于针对特定类型的疾病开发更适合的疗法。我们假设ER +和ER-乳腺癌患者的组织学正常上皮之间的基因表达存在差异。我们发现ER +患者的组织学正常上皮中存在与ER +癌变有关的途径（ESR和GATA3途径），而免疫反应基因占ER-患者组织学上正常上皮中表达较高的基因的32％。样品之间鉴定出的差异证明了在特定患者人群中乳腺癌致癌作用的明显早期改变。识别这些早期变化将有助于准确确定风险并开发用于乳腺癌治疗和预防的更具体的药物。

著录项

  • 作者

    Graham, Kelly A.;

  • 作者单位

    Boston University.;

  • 授予单位 Boston University.;
  • 学科 Biology Genetics.Health Sciences Pathology.Health Sciences Oncology.
  • 学位 Ph.D.
  • 年度 2010
  • 页码 204 p.
  • 总页数 204
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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