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首页> 外文期刊>BMC Medical Genomics >Association between STAT4 gene polymorphism and type 2 diabetes risk in Chinese Han population
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Association between STAT4 gene polymorphism and type 2 diabetes risk in Chinese Han population

机译：STAT4基因多态性与中国汉族人群中2型糖尿病患者的关联

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Evidence from genetic epidemiology indicates that type 2 diabetes (T2D) has a strong genetic basis. Activated STAT4 has an inflammatory effect, and STAT4 is an important mediator of inflammation in diabetes. Our study aimed to study the association between STAT4 single nucleotide polymorphisms (SNPs) and T2D susceptibility in Chinese Han population. We conducted a 'case–control' study among 500 T2D patients and 501 healthy individuals. 5 candidate STAT4 SNPs were successfully genotyped. The association between SNPs and T2D susceptibility under different genetic models was evaluated by logistic regression analysis. ‘SNP-SNP’ interaction was analyzed and completed by multi-factor dimensionality reduction (MDR). Finally, we evaluated the differences of clinical characteristics under different genotypes by one-factor analysis of variance. The overall results showed that STAT4 rs3821236 was associated with increasing T2D risk under allele (OR 1.23, p?=?0.020), homozygous (OR 1.51, p?=?0.025), dominant (OR 1.36, p?=?0.029), and additive models (OR 1.23, p?=?0.020). The results of stratified analysis showed that rs3821236, rs11893432, and rs11889341 were risk factors for T2D among participants?≤?60?years old. Only rs11893432 was associated with increased T2D risk among female participants. There was also a potential association between rs3821236 and T2D with nephropathy risk. STAT4 rs11893432, rs7574865 and rs897200 were significantly associated with lysophosphatidic acid, cystatin C and thyroxine t4, respectively. The genetic polymorphisms of STAT4 is potentially associated with T2D susceptibility of Chinese population. In particular, rs3821236 is significantly associated with T2D risk both in the overall and several subgroup analyses. Our study may provide new ideas for T2D individualized diagnosis/protection.
机译：来自遗传流行病学的证据表明2型糖尿病（T2D）具有强遗传基础。活化的STAT4具有炎症作用，STAT4是糖尿病中炎症的重要介质。我们的研究旨在研究STAT4单核苷酸多态性（SNP）与中国汉族人群T2D易感性之间的关联。我们在500T2D患者和501名健康个体中进行了“病例控制”研究。 5候选STAT4 SNP已成功进行基因分型。通过逻辑回归分析评估了不同遗传模型下SNP和T2D易感性之间的关联。通过多因素维度减少（MDR）分析并完成了“SNP-SNP”的相互作用。最后，我们通过单因素分析评估了不同基因型下的临床特征的差异。总体结果表明，STAT4 RS3821236与等位基因下的T2D风险增加有关（或1.23，P？0.020），纯合（或1.51，P？= 0.025），主导（或1.36，P？= 0.029），和添加剂模型（或1.23，p？= 0.020）。分层分析结果表明，RS3821236，RS11893432和RS11889341是参与者中T2D的风险因素？≤？60？岁。只有RS11893432只与女性参与者之间的T2D风险增加有关。 RS3821236和T2D之间也存在肾病风险的潜在关联。 STAT4 RS11893432，RS7574865和RS897200分别与溶血磷脂酸，胱抑素C和甲状腺素T4显着相关。 STAT4的遗传多态性可能与中国人群T2D易感性有关。特别是，RS3821236在整体和几个子组分析中，与T2D风险显着相关。我们的研究可能为T2D个性化诊断/保护提供新的思路。

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