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首页> 外文期刊>BMC Immunology >Selenium-related nutritional status in patients with common variable immunodeficiency: association with oxidative stress and atherosclerosis risk
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Selenium-related nutritional status in patients with common variable immunodeficiency: association with oxidative stress and atherosclerosis risk

机译：均硒相关的营养状况患者常见的可变免疫缺陷：与氧化应激和动脉粥样硬化风险相关联

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Common variable immunodeficiency (CVID) is an inborn errors of immunity, that leads to recurrent chronic infections and autoimmune/ inflammatory diseases and neoplasms. It is considered that these condition is related to persistent this?immune-inflammatory stimulation and increased oxidative stress. A positive impact on the survival of patients with an inborn error of immunity was observed with advanced clinical care protocols, thus raising concerns about the risk of developing other associated chronic diseases, such as atherosclerosis. Studies suggest that selenium (Se) is a protective trace element against damage caused by oxidative stress. Thus, it is postulated that adequate consumption reduces the risk of some chronic diseases. Se?median levels (ug/L) [45.6 (37.3–56.2) vs. 57.8 (46.0–66.0); p?=?0.004] and GPX activity (U/L) [7682 (6548–8446) vs. 9284(8440–10,720); p?=?0,002) were significantly lower in patients compared to controls. Inadequacy of Se levels was observed in 50% of the patients. There was a higher percentage of high values of C-reactive protein in the group of CVID patients compared to controls [8 (36.4%) vs. 2 (11.1%); p?=?0.082]. Higher concentrations of oxidized LDL (45.3?mg/dL vs. 33.3?mg/dL; p?=?0.016) and lower concentrations of Apo A-1 (98.5?mg/dL) vs. 117.0?mg/dL; p?=?0.008) were observed in the CVID group compared to the control. There was a significant and positive correlation between Se?plasma levels and apolipoprotein A-1 concentrations in CVID group (rho?=?0.577; p?=?0.001). Se values less than 46 μg / L (OR?=?3.590; 95% CI 1.103 to 11.687; p?=?0.034) and GPX activity below the 4th quartile (OR?=?21.703; 95% CI 2.534 to 185.914; p?=?0.005) were independently associated, after adjustment for age, overweight and dyslipidemia, with the?CVID group (Table 5). This study showed an higher percentage of high us-CRP, lower values of plasma Se and GPX activity, higher concentrations of LDLox and lower levels of Apo A-1 in CVID patients in comparison to controls, suggesting oxidative stress and cardiovascular risk.These data point to the importance of assessing the Se status and cardiovascular risk in these patients.
机译：常见的可变免疫缺陷（CVID）是一种原始的免疫误差，导致复发性慢性感染和自身免疫/炎性疾病和肿瘤。认为这些病症与持续这种情况有关？免疫炎症刺激和增加的氧化应激。通过先进的临床护理方案，观察到对抗免疫的原始误差患者存活的积极影响，从而提高了对发展其他相关慢性病的风险，例如动脉粥样硬化。研究表明，硒（SE）是一种免受氧化应激引起的损伤的保护性微量元素。因此，假定充分的消费降低了一些慢性疾病的风险。 SE？中位水平（UG / L）[45.6（37.3-56.2）与57.8（46.0-66.0）; p？= 0.004]和GPX活性（U / L）[7682（6548-8446）与9284（8440-10,720）;与对照相比，P？=Δ0,002）显着降低。在50％的患者中观察到SE水平的不足。与对照组相比，CVID患者组中C反应蛋白的高值较高百分比[8（36.4％）与2（11.1％）; p？= 0.082]。较高浓度的氧化LDL（45.3×mg / dl与33.3×mg / d1;p≤x≤0.016）和较低浓度的apo a-1（98.5×mg / dl）与117.0？mg / dl;与对照相比，在CVID组中观察到p？= 0.008）。 CVID基团的血浆水平与载脂蛋白A-1浓度之间存在显着且阳性相关性（rho？= 0.577; p？= 0.001）。 Se值小于46μg/ L（或？3.590; 95％CI 1.103至11.687; p？= 0.034）和GPX活性以下4th四分位数（或？=？21.703; 95％CI 2.534至185.914; p ？=Δ0.005）独立相关，在调整年龄，超重和血脂血症后，用βCVID组（表5）。该研究显示出高US-CRP，较低的血浆SE和GPX活性值，CVID患者中较高浓度的LDLOX和降低APO A-1水平，表明氧化应激和心血管风险。这些数据指向评估这些患者中SE状态和心血管风险的重要性。

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