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首页> 外文期刊>BMC Neuroscience >Eosinophil-to-monocyte ratio is a potential biomarker in the prediction of functional outcome among patients with acute ischemic stroke
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Eosinophil-to-monocyte ratio is a potential biomarker in the prediction of functional outcome among patients with acute ischemic stroke

机译：嗜酸性粒细胞至单核细胞比是急性缺血性卒中患者的功能结果预测潜在的生物标志物

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It has been shown that eosinophils are decreased and monocytes are elevated in patients with acute ischemic stroke (AIS), but the impact of eosinophil-to-monocyte ratio (EMR) on clinical outcomes among AIS patients remains unclear. We aimed to determine the relationship between EMR on admission and 3-month poor functional outcome in AIS patients. A total of 521 consecutive patients admitted to our hospital within 24?h after onset of AIS were prospectively enrolled and categorized in terms of quartiles of EMR on admission between August 2016 and September 2018. The endpoint was the poor outcome defined as modified Rankin Scale score of 3 to 6 at month 3 after admission. As EMR decreased, the risk of poor outcome increased (p??0.001). Logistic regression analysis revealed that EMR was independently associated with poor outcome after adjusting potential confounders (odds ratio, 0.09; 95% CI 0.03–0.34; p?=?0.0003), which is consistent with the result of EMR (quartile) as a categorical variable (odds ratio, 0.23; 95% CI 0.10–0.52; ptrend??0.0001). A non-linear relationship was detected between EMR and poor outcome, whose point was 0.28. Subgroup analyses further confirmed these associations. The addition of EMR to conventional risk factors improved the predictive power for poor outcome (net reclassification improvement: 2.61%, p?=?0.382; integrated discrimination improvement: 2.41%, p??0.001). EMR on admission was independently correlated with poor outcome in AIS patients, suggesting that EMR may be a potential prognostic biomarker for AIS.
机译：已经表明，嗜酸性粒细胞减少，急性缺血性卒中（AIS）患者升高了单核细胞，但嗜酸性粒细胞对单核细胞比率（EMR）对AIS患者的临床结果的影响尚不清楚。我们旨在确定EMR在AIS患者的入学和3个月差的功能结果之间的关系。在2016年8月和2018年8月间入场时，共参加并分类AIS后，共参加了521名患者在24岁以下的患者入住，并分类为EMR的四分位数。该终点是定义为改进的Rankin规模得分的差的结果在入学后3月3日3至6日。随着EMR减少，结果差的风险增加（P？＆？0.001）。逻辑回归分析表明，在调整潜在混淆后，EMR独立关联，在调整潜在混淆后的结果不良（0.09; 95％CI 0.03-0.34; p？= 0.0003），这与EMR（四分位数）作为分类的结果一致变量（差距，0.23; 95％CI 0.10-0.52; PTREND？＆？0.0001）。在EMR和差的结果之间检测到非线性关系，其点为0.28。亚组分析进一步证实了这些协会。向常规风险因素添加EMR改善了预测的能力，以获得较差的结果（净重新分类：2.61％，P？= 0.382;综合辨别改善：2.41％，P？0.001）。入学EMR与AIS患者的差异无关，表明EMR可能是AIS的潜在预后生物标志物。

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